PMID: 15241752Jul 9, 2004Paper

The effectiveness of anticoagulant and antiplatelet agents in preventing venous thromboembolism during stroke rehabilitation: a historical cohort study

Archives of Physical Medicine and Rehabilitation
R L HarveyE J Roth

Abstract

To determine the effectiveness of anticoagulant and antiplatelet agents in preventing venous thromboembolism (VTE) during stroke rehabilitation. Historical cohort study. Acute inpatient rehabilitation hospital. Consecutive patients (N=1506) with ischemic and hemorrhagic stroke admitted for rehabilitation. Documented use of anticoagulants (warfarin or anticoagulant doses of heparin), heparin in prophylactic doses, and antiplatelet agents. Occurrence of deep vein thrombosis detected by ultrasound or venography or pulmonary embolism detected by ventilation perfusion scan, spiral computed tomography, or pulmonary angiography. Fifty-eight VTE events occurred (3.9% incidence or 1.36 events per 1000 patient days), with higher risk in patients with severe stroke. Only therapeutic anticoagulation had a statistically significant protective effect for VTE risk in univariate analysis (odds ratio [OR]=.44; 95% confidence interval [CI],.20-.98). After adjusting for multiple medication use and other factors, including age, stroke onset to admission interval, length of rehabilitation stay, cause of stroke, and admission National Institutes of Health Stroke Scale score, therapeutic anticoagulation gave strong protection against VTE (OR=.37; 95%...Continue Reading

References

Sep 1, 1976·Stroke; a Journal of Cerebral Circulation·T Kitamura, K Ito
Jun 1, 1989·Archives of Neurology·L B GoldsteinJ N Davis
Jul 1, 1981·Stroke; a Journal of Cerebral Circulation·J V BoundsH Okazaki
Apr 1, 1995·Archives of Physical Medicine and Rehabilitation·G PambiancoP Landau
Mar 1, 1996·Stroke; a Journal of Cerebral Circulation·R J DavenportC P Warlow
Jun 1, 1997·Stroke; a Journal of Cerebral Circulation·A W HeinemannE J Roth
Feb 7, 2001·Stroke; a Journal of Cerebral Circulation·E J RothS Diaz

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Citations

Jan 16, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C AndréM M Fukujima
Dec 27, 2008·The Keio Journal of Medicine·Yukihiro Hara
Nov 22, 2005·Disability and Rehabilitation·Sam-Gyu LeeJae-Gyu Kim
Jul 28, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Brian M KellyThomas W Wakefield
Aug 4, 2009·Thrombosis Research·Walter AgenoUNKNOWN Italian Society for Haemostasis and Thrombosis
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·David G Sherman
Sep 1, 2015·Journal of the Neurological Sciences·Zhou ZengJie Zhang
Jun 11, 2005·Journal of Thrombosis and Haemostasis : JTH·P W KamphuisenM Sebastianelli
Jun 8, 2012·Journal of the American Academy of Nurse Practitioners·Myunghan Choi, Melvin Hector
Oct 11, 2005·Archives of Physical Medicine and Rehabilitation·Richard D Wilson, Patrick K Murray
Jun 8, 2015·American Journal of Therapeutics·Pramod Reddy, Lori Dupree
May 23, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Luca MasottiWalter Ageno
Jan 13, 2015·Stroke; a Journal of Cerebral Circulation·Shyam PrabhakaranDawn O Kleindorfer
Nov 3, 2012·Stroke; a Journal of Cerebral Circulation·Alexander G G TurpieUNKNOWN EXCLAIM Investigators

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