PMID: 9187478Jun 1, 1997Paper

The effectiveness of clonazepam on the Rolandic discharges

Brain & Development
A MitsudomeT Yamada

Abstract

Rolandic discharge (RD), noted in the electroencephalography (EEG) of patients with benign epilepsy in childhood with centrotemporal spikes (BECCT) has several unique features. One feature is that the amount or frequency of RDs does not correlate well with the incidence of seizures in BECCT although it is a key finding in the diagnosis of this epileptic syndrome. In this study, we examined the efficacy of antiepileptic drugs focusing on the disappearance of RDs in relationship with seizure control. Forty patients with BECCT who were not medically treated prior to this study were randomly sorted into three groups. Twenty patients were assigned for clonazepam (CZP) treatment, 10 patients for valproate (VPA) and the remaining 10 patients for carbamazepine (CBZ). Each drug was administered for 4 consecutive weeks. EEGs were recorded twice during the study, before and 4 weeks after the medication trial. The effects of each treatment on RDs were assessed. RDs disappeared in 15 of the 20 cases treated with CZP (75%) within 4 weeks while the same was observed in only one of the 10 cases treated with VPA (10%). CBZ failed to demonstrate any effect on RD. In the group treated with CZP, there were no differences in seizure incidence, seiz...Continue Reading

References

Apr 1, 1975·Archives of Neurology·P Lerman, S Kivity
Jan 1, 1974·European Neurology·G Scollo-LavizzariN De La Cruz
Jan 1, 1973·Acta Psychiatrica Scandinavica. Supplementum·C E Hansen, P Kragh-Sorensen
Dec 1, 1993·Seizure : the Journal of the British Epilepsy Association·J ChatawayJ S Duncan

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Citations

Jun 26, 2012·Pediatrics International : Official Journal of the Japan Pediatric Society·Mohammed Ghiath ShamdeenSascha Meyer
Dec 22, 1999·Seizure : the Journal of the British Epilepsy Association·T ObeidC Harris
Apr 25, 2000·Seizure : the Journal of the British Epilepsy Association·N Gordon
Oct 26, 2016·Pharmacotherapy·Marília Silveira de Almeida CamposLeonardo Régis Leira Pereira
Feb 9, 2007·Expert Review of Neurotherapeutics·Stavros M Hadjiloizou, Blaise F D Bourgeois
Nov 20, 2019·The Cochrane Database of Systematic Reviews·Francesco BrigoSimona Lattanzi

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