The effectiveness of desmopressin in the treatment of childhood nocturnal enuresis: predicting response using pretreatment variables

British Journal of Urology
R ButlerE Redfern

Abstract

To determine the factors that predict the effectiveness of desmopressin in the treatment of childhood nocturnal enuresis. Sixty-six children with monosymptomatic nocturnal enuresis were treated with intranasal or oral desmopressin for a 4-week period. starting with a standard dose of 20 microg (0.2 mg oral) and increasing after 2 weeks where no progress was apparent to 40 microg (0.4 mg oral). Before treatment a range of variables (demographic, situational, enuretic history, physiological, parental attitude and child) were recorded. Three parameters of success acted as dependent variables, with stepwise linear regression models used to determine pretreatment predictors of success with desmopressin. Each outcome variable produced a very similar model of predictors. Success, as assessed by the most dry nights over a 14-night period, was associated with less severe enuresis before treatment, a parental belief that the child's enuresis was unstable and higher birthweight. From the analysis, a model of arginine vasopressin release is proposed and the clinical implications of the findings addressed.

References

Jun 1, 1975·Behaviour Research and Therapy·R T Morgan, G C Young
Apr 1, 1991·The Journal of Urology·P Terho
Oct 1, 1990·Archives of Disease in Childhood·J B Devlin, C O'Cathain
Dec 1, 1989·Developmental Medicine and Child Neurology·M R Järvelin
Jun 1, 1989·Archives of Disease in Childhood·W I Forsythe, R J Butler
Jul 1, 1988·Journal of Child Psychology and Psychiatry, and Allied Disciplines·R J ButlerW I Forsythe
Dec 1, 1988·Journal of Abnormal Child Psychology·W G Wagner, J T Johnson
Jun 1, 1987·Pediatric Clinics of North America·A C Novello, J R Novello
Jan 1, 1986·Archives of Disease in Childhood·S Wille
Nov 1, 1986·Archives of Disease in Childhood·S B Dimson
Aug 1, 1987·Archives of Disease in Childhood
Jan 1, 1986·Behaviour Research and Therapy·R J ButlerW I Forsythe
Jan 1, 1986·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·G GeffkenD Walker
Jan 1, 1985·The Journal of Urology·P S PedersenS S Kjøller
Aug 1, 1972·Behaviour Research and Therapy·S H Lovibond
Oct 1, 1983·American Journal of Diseases of Children·E M PostK Miller
May 1, 1984·The Journal of Urology·P Terho, M Kekomäki
Dec 1, 1983·Journal of Health and Social Behavior·S CohenR Mermelstein
Feb 1, 1983·Developmental Medicine and Child Neurology·S DischeD Hand
Aug 1, 1982·The Journal of Pediatrics·W WagnerJ Wittner
Jan 1, 1982·Behaviour Research and Therapy·J Bollard, T Nettelbeck
Oct 1, 1982·Journal of Child Psychology and Psychiatry, and Allied Disciplines·P GriffithsR McWilliam
Aug 1, 1994·Journal of Consulting and Clinical Psychology·A C HoutsH Abramson
May 1, 1993·Behaviour Research and Therapy·R J ButlerI Forsythe
Jun 1, 1996·European Child & Adolescent Psychiatry·R W Dittmann, S Wolter

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Citations

Dec 18, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Cherry Fai-Ngo NgUNKNOWN Hong Kong Childhood Enuresis Study Group
Oct 9, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·E J Mikkelsen
Jan 8, 2009·International Journal of Clinical Practice·H LottmannJ P Norgaard
Apr 20, 1999·Archives of Disease in Childhood·H DevittG Roberts
Aug 21, 2007·The Journal of Urology·Boris ChertinAmicur Farkas
Nov 10, 2004·Clinical Psychology Review·Richard J Butler
May 26, 2004·Journal of Child Health Care : for Professionals Working with Children in the Hospital and Community·Joanna M Heap
Sep 12, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Yanli MaYing Shen
Jun 19, 2004·Scandinavian Journal of Urology and Nephrology·Richard J ButlerDianne Doherty-Williams
Nov 30, 2000·Scandinavian Journal of Urology and Nephrology·R J Butler, P Holland
Feb 17, 2005·International Journal of Adolescent Medicine and Health·Orhan DermanErol Kinik
Oct 14, 2006·Current Opinion in Urology·S Agarwal
May 31, 2003·Scandinavian Journal of Urology and Nephrology·Sarah Anne RedsellJonathan Evans

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