The effectiveness of different singly administered high doses of buprenorphine in reducing suicidal ideation in acutely depressed people with co-morbid opiate dependence: a randomized, double-blind, clinical trial

Trials
Jamshid AhmadiZahra Ehsaei

Abstract

Buprenorphine is usually administered to treat opioid use disorder and pain syndromes. This research presents the first study regarding the effectiveness of different singly administered high doses of buprenorphine (a partial opioid agonist (of μ-opioid receptors), a potent opioid antagonist (of κ-receptors) and a partial agonist of nociception receptors) in reducing suicidal ideation in acutely depressed people with co-morbid opiate dependence. It follows small studies that suggest that ultra-low-dose buprenorphine may be useful in reducing suicidal ideation. The goal of this study was to describe the outcome of different doses of buprenorphine on suicidal opioid-dependent patients over a 3-day interval, by conducting a randomized clinical trial. Fifty-one suicidal male inpatients who fulfilled the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for both opioid dependence and major depressive disorder were randomized to three groups (n = 17 per group) to receive a single, sublingual dose of buprenorphine (32 mg, 64 mg, or 96 mg). Out of 51 participants, there were 47 patients; 16 (34.04%) received 32 mg, 17 (36.17%) received 64 mg, and 14 (29.78%) received 96 mg of sublingual buprenorphine...Continue Reading

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Citations

Jan 10, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Lynn WebsterTheresa Mallick-Searle
Oct 2, 2020·The American Journal of Psychiatry·J John Mann, Mina M Rizk
Oct 28, 2019·Nature Reviews. Disease Primers·Gustavo TureckiBarbara H Stanley
Mar 25, 2020·Psychological Medicine·Caitlin A Madison, Shoshana Eitan
Apr 14, 2020·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Philippe PfeiferThomas Reisch
May 13, 2020·Pain Management·Martin HaleRichard Rauck
Jan 10, 2020·Annual Review of Pharmacology and Toxicology·Moriah L JacobsonIrwin Lucki
Jul 15, 2020·The American Journal on Addictions·Ori-Michael BenhamouLidia Klepacz
Mar 23, 2021·Current Addiction Reports·Mina M RizkBarbara Stanley
Mar 31, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Aiste LengvenytePhilippe Courtet
Apr 10, 2021·Journal of Pain Research·Joseph V PergolizziGiustino Varrassi
Apr 18, 2020·ACS Chemical Neuroscience·Jillian L Kyzer, Cody J Wenthur
Dec 9, 2021·Molecular Medicine Reports·Qier ZhouNa Liang

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