The effectiveness of excimer laser angioplasty to treat coronary in-stent restenosis with peri-stent calcium as assessed by optical coherence tomography

EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Tetsumin LeeAkiko Maehara

Abstract

We aimed to evaluate the effectiveness of excimer laser coronary angioplasty (ELCA) to treat in-stent restenosis (ISR) due to peri-stent calcium-related stent underexpansion as assessed by optical coherence tomography (OCT). We studied 81 patients (81 lesions with ISR, stent underexpansion, and peri-stent calcium >90°) who underwent OCT imaging both pre and post percutaneous coronary intervention and compared lesions treated with ELCA (n=23) vs. without ELCA (n=58). ELCA use was associated with more calcium fracture (ELCA: 61%, non-ELCA: 12%, p<0.01), larger final minimum lumen area (ELCA: 4.76 mm2 [3.25, 5.57], non-ELCA: 3.46 mm2 [2.80, 4.13], p<0.01), and a larger previously implanted stent area (ELCA: 6.15 mm2 [4.83, 7.09], non-ELCA: 4.65 mm2 [3.84, 5.40], p<0.01). In the multivariable model, ELCA use was associated with peri-stent calcium fracture (odds ratio 46.5, 95% confidence interval: 6.8, 315.9, p<0.001) that, in turn, was associated with final larger lumen and stent dimensions. Finally, contrast injection during ELCA was associated with multiple calcium fractures and fractures even in thicker calcium. ELCA is effective for treating ISR with underexpansion by disrupting peri-stent calcium, facilitating better expansio...Continue Reading

References

Jan 1, 2013·The American Journal of Cardiology·Diaa A HakimAkiko Maehara
Dec 3, 2013·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Azeem LatibAntonio Colombo
Jul 16, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuhei KobayashiKiyoshi Yoshida
Mar 11, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Takashi AshikagaMitsuaki Isobe
Mar 24, 2015·JACC. Cardiovascular Imaging·Takashi KuboTakashi Akasaka
Nov 14, 2015·JACC. Cardiovascular Imaging·Francesco PratiGary S Mintz
Apr 9, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Tadashi MiyazakiAntonio Colombo
Sep 2, 2016·Circulation. Cardiovascular Interventions·Daisuke NakamuraHiram G Bezerra
Nov 20, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Luca A FerriAzeem Latib
Dec 16, 2016·Case Reports in Cardiology·K ShaikhT Stys
Apr 26, 2017·Coronary Artery Disease·Gary S Mintz
Feb 6, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Akiko FujinoAkiko Maehara

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Citations

Jan 17, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Keir McCutcheonTom Adriaenssens
Dec 24, 2019·Interventional Cardiology·Carlotta Sorini DiniCarlo Di Mario
Dec 24, 2019·Interventional Cardiology·Evan ShlofmitzZiad A Ali
Aug 14, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Dong YinUNKNOWN Collaborators
Oct 10, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Annapoorna S KiniSamin Sharma
Jan 15, 2021·Circulation. Cardiovascular Interventions·Mohammed ShahKalpa De Silva
Nov 23, 2020·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Joseph De Gregorio, Yasuhiro Aoki
Mar 6, 2021·Current Cardiology Reports·Keyvan Karimi GalougahiZiad A Ali
Mar 16, 2021·Journal of Cardiology Cases·Kenji Yaginuma, Gerald S Werner
Nov 8, 2020·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Rayji S TsutsuiRishi Puri
May 26, 2021·Cardiovascular Revascularization Medicine : Including Molecular Interventions·George KassimisStavros Hadjimiltiades
Sep 5, 2020·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Gianluca CaiazzoLuciano Fattore
Oct 12, 2020·Reviews on Recent Clinical Trials·Nooraldaem YousifHusam A Noor

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