The Effectiveness of Human Parathyroid Hormone and Low-Intensity Pulsed Ultrasound on the Fracture Healing in Osteoporotic Bones

Annals of Biomedical Engineering
Karima Q MansjurEiji Tanaka

Abstract

Osteoporotic fracture has become a major public health problem, and until today, the treatments available are not satisfactory. While there is growing evidence to support the individual treatment of parathyroid hormone (PTH) administration and low-intensity pulsed ultrasound (LIPUS) exposure as respectively systemic and local therapies during osteoporotic fracture healing, their effects have not yet been investigated when introduced concurrently. This study aimed to evaluate the effects of combined treatment with PTH (1-34) and LIPUS on fracture healing in ovariectomized (OVX) rats. Thirty-two, 12-week-old female Sprague-Dawley rats were OVX to induce osteoporosis. After 12 weeks, the rats underwent surgery to create bilateral mid-diaphyseal fractures of proximal tibiae. All animals were randomly divided into 4 groups (n = 8 for each): control group as placebo, PTH group, LIPUS group, and combined group. PTH group had PTH administration at a dose of 30 μg/kg/day for 3 days/week for 6 weeks. LIPUS group received ultrasound 5 days/week for 20 min/day for 6 weeks and combined group had both PTH administration and LIPUS exposure for 6 weeks. Fracture healing was observed weekly by anteroposterior radiography and micro-CT. Five week...Continue Reading

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Citations

May 24, 2017·The Journal of International Medical Research·Wei-Long LiQing-Jiang Pang
Sep 30, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wen ZhangChunli Song
Aug 30, 2018·The Journal of Craniofacial Surgery·Servet AkyildizSirmahan Cakarer
Aug 23, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Bin LiuHaiyang Yu
Jul 21, 2017·Lasers in Medical Science·Mohammadjavad FredoniMohammad Bayat
Jun 10, 2020·Annals of Biomedical Engineering·Eiji TanakaAkihito Yamamoto

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