The Effectiveness of Influenza Vaccination in Different Groups

Expert Review of Vaccines
Angela DomínguezNuria Torner

Abstract

Annual administration of the seasonal influenza vaccine, especially to persons known to be at elevated risk for developing serious complications, is the focus of current efforts to reduce the impact of influenza. The main factors influencing estimated inactivated influenza vaccine efficacy and effectiveness, the results obtained in different population groups, current vaccination strategies and the possible advantages of new vaccines are discussed. The available evidence suggests that influenza vaccines are less effective in the elderly than in young adults, but vaccination is encouraged by public health institutions due to higher mortality and complications. There is no consensus on universal vaccination of children yet economic studies suggest that yearly paediatric vaccination is cost saving. The benefits of herd immunity generated by paediatric vaccination require further study. Newer vaccines should be more and more-broadly protective, stable, easy to manufacture and administer and highly immunogenic across all population groups.

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Citations

Sep 14, 2016·Transactions of the Royal Society of Tropical Medicine and Hygiene·Michelle SteeperKatie L Flanagan
Jun 16, 2017·Human Vaccines & Immunotherapeutics·Maria R Castrucci
May 16, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Iván Martínez-BazJesús Castilla
Sep 27, 2019·Vaccines·Huapeng FengYoshihiro Kawaoka
Jul 12, 2017·International Journal of Environmental Research and Public Health·Diana ToledoAngela Domínguez
Feb 9, 2019·Frontiers in Microbiology·Huapeng FengYoshihiro Kawaoka
Jul 15, 2020·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Simon de LusignanTristan Clark
Mar 12, 2021·Human Vaccines & Immunotherapeutics·Simin WenYuelong Shu

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