The effectiveness of pancreatic enzyme replacement therapy for malabsorption in advanced pancreatic cancer, a pilot study

Palliative Care
Amanda LandersMatthew Strother

Abstract

Advanced adenocarcinoma of the pancreas has a globally poor prognosis. One of the characteristic features of pancreatic cancer (PC) is pancreatic exocrine insufficiency (PEI). This leads to a malabsorption syndrome and subsequent digestive symptoms. Given the high prevalence of PEI and malabsorption in PC, empiric use of pancreatic enzyme replacement therapy (PERT) is recommended. The aim of this pilot study was to determine the potential efficacy of PERT in improving symptoms and quality of life in those with metastatic PC. The study recruited patients with advanced PC referred to a specialist palliative care service. Following an initial assessment, patients were commenced on pancrealipase 25,000IU (Creon) and reassessed after 1 week and 3 weeks post-initiation of supplementation. These assessments included demographics, malabsorption symptom checklist, and completion of two validated quality-of-life questionnaires, the European Organisation for Research and Treatment of Cancer QLQ-C30 and QLQ-PAN26. PERT was associated with statistically significant improvement of symptoms in both the general (QLQ-C30) and pancreatic cancer specific tool (PAN26). Within 1 week of PERT initiation, there was a reduction in diarrhoea scores (26...Continue Reading

References

Apr 19, 1973·The New England Journal of Medicine·E P DiMagnoW H Summerskill
May 1, 1993·Gut·L GuarnerJ R Malagelada
Feb 1, 1996·Journal of Gastroenterology·H WakasugiM Abe
Mar 8, 2003·International Journal of Gastrointestinal Cancer·Anthony R J PhillipsJohn A Windsor
Mar 20, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Wendy DavidsonUNKNOWN Cancer Cachexia Study Group
Mar 24, 2005·The American Journal of Gastroenterology·Deborah FitzsimmonsColin D Johnson
May 13, 2005·Gut·UNKNOWN Pancreatric Section, British Society of GastroenterologyUNKNOWN Special Interest Group for Gastro-Intestinal Radiology
Apr 8, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Knut Jørgen LaboriJon Håvard Loge
Nov 23, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Joe Matsumoto, L William Traverso
Feb 26, 2011·Journal of Gastroenterology and Hepatology·J Enrique Domínguez-Muñoz
Nov 19, 2011·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Christopher M HalloranPaula Ghaneh
May 11, 2012·The Medical Journal of Australia·Antony G SpeerMichael Jefford
Jun 9, 2012·Journal of the National Comprehensive Cancer Network : JNCCN·Margaret A TemperoUNKNOWN National Comprehensive Cancer Networks
Jun 20, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Edmée C M SikkensMarco J Bruno
Feb 12, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·H M Gooden, K J White
Apr 11, 2014·Journal of Clinical Gastroenterology·Edmée C M SikkensMarco J Bruno
Aug 29, 2014·BMJ Supportive & Palliative Care·Amanda LandersHelen Brown
Sep 13, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Sang Myung WooWoo Jin Lee

❮ Previous
Next ❯

Citations

Aug 6, 2019·Cancer·Gordon T MoffatEileen M O'Reilly
Jan 26, 2020·Cancers·Raffaele PezzilliMassimo Falconi
May 30, 2020·Nutrients·Kalliopi Anna PouliaMichalis V Karamouzis
Aug 6, 2020·Journal of Clinical Medicine·Sara PuscedduFilippo de Braud
May 1, 2021·Cancers·Sarah Powell-BrettKeith J Roberts

❮ Previous
Next ❯

Software Mentioned

PERT
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Oncology : a Journal of the Royal College of Radiologists
L Watson
Gastroenterology & Hepatology
J Enrique Domínguez-Muñoz
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
R PezzilliR Corinaldesi
© 2022 Meta ULC. All rights reserved