The Effectiveness of Pharmacological Agents for the Treatment of Uveitic Macular Edema (UMO): A Systematic Review.

Ocular Immunology and Inflammation
Mohammad O TallouziAlastair K Denniston

Abstract

Purpose: To conduct a systematic review of effectiveness of pharmacological therapies for treatment of Uveitic Macular Edema (UMO). Method/Design: Comparative studies of pharmacological therapies in patients with UMO were identified in Cochrane CENTRAL/MEDLINE/EMBASE/CINAHL/trials registers (February 2017). PROSPERO registration: CRD42015019170. Results: Thirty-one studies were included. Corticosteroids were the most frequently studied (n = 20). Corticosteroids (all forms) were consistently of greater/equal efficacy to active comparators; for anti-VEGF (n = 4) improvement, best-corrected visual acuity (BCVA) and central macular thickness (CMT) were mostly less than local corticosteroid injection; for interferon (n = 1) improvement BCVA and CMT were greater than the comparator of methotrexate; for topical indomethacin (n = 1) improvement, BCVA and CMT were greater than placebo. Non-steroidal anti-inflammatory drugs, carbonic anhydrase inhibitors, and vitamin E (n = 5) were not effective for these outcomes. Conclusion: The review highlights areas where the evidence base is still lacking, and appropriately focused trials are needed to inform best treatment to tackle this sight-threatening condition.

References

Feb 15, 1987·American Journal of Ophthalmology·E Bloch-Michel, R B Nussenblatt
Apr 1, 1996·The British Journal of Ophthalmology·A RothovaA Kijlstra
Feb 25, 2000·BMJ : British Medical Journal·P J McCluskeyS Lightman
Jul 20, 2004·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·O M DurraniP I Murray
Oct 19, 2004·American Journal of Ophthalmology·Nikos N MarkomichelakisPetros P Sfikakis
Sep 21, 2005·Ophthalmology·Howesen KokSusan Lightman
Oct 1, 2005·American Journal of Ophthalmology·Douglas A JabsUNKNOWN Standardization of Uveitis Nomenclature (SUN) Working Group
Jan 3, 2006·American Journal of Ophthalmology·Robert B NussenblattRonald Buggage
Aug 1, 2006·Ophthalmology·Charlotte W T A LardenoyeAniki Rothova
Aug 19, 2006·The British Journal of Ophthalmology·G J WilliamsJ A Olson
Mar 14, 2007·Archives of Ophthalmology·Baruch D KuppermannUNKNOWN Dexamethasone DDS Phase II Study Group
Nov 14, 2007·Clinical & Experimental Ophthalmology·Surbhit Choudhry, Sudipta Ghosh
Feb 26, 2008·International Ophthalmology·Piergiorgio NeriAlfonso Giovannini
Sep 10, 2008·Archives of Ophthalmology·David G CallananTimothy L Comstock
Dec 10, 2008·Ocular Immunology and Inflammation·Pradeep VenkateshSatpal Garg
Mar 10, 2009·American Journal of Ophthalmology·George A WilliamsUNKNOWN Dexamethasone DDS Phase II Study Group
Apr 7, 2009·Ophthalmology·Simon R J TaylorSue L Lightman
May 12, 2009·American Journal of Ophthalmology·Nisha R AcharyaSalena M Lee
Feb 23, 2010·International Journal of Surgery·David MoherUNKNOWN PRISMA Group
Mar 24, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Masoud SoheilianGholam A Peyman
Jan 12, 2011·Archives of Ophthalmology·Careen LowderUNKNOWN Ozurdex HURON Study Group
Aug 25, 2011·American Journal of Ophthalmology·Elizabeth A SugarUNKNOWN Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group
Mar 23, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Alaa E RadwanC Stephen Foster
May 24, 2013·Ocular Immunology and Inflammation·Masoud SoheilianRoham Soheilian
Jun 22, 2013·American Journal of Ophthalmology·Friederike MackensenMatthias D Becker
Jun 28, 2013·Indian Journal of Ophthalmology·Narsing A Rao
Jun 29, 2013·Clinical Ophthalmology·Rushmia KarimSamantha Fraser-Bell
Feb 13, 2014·Investigative Ophthalmology & Visual Science·Pia AllegriGiuseppina Marrazzo
Jun 20, 2015·Journal of Ophthalmology·Marwan R AbdulaalRola N Hamam
Aug 27, 2015·Ocular Immunology and Inflammation·Joo Young Shin, Hyeong Gon Yu
Sep 10, 2015·Current Pharmaceutical Design·Robert J Barry, Alastair K Denniston
Sep 12, 2015·Ophthalmology·Oren Tomkins-NetzerUNKNOWN Multicenter Uveitis Steroid Treatment Trial Research Group
Jul 9, 2016·Systematic Reviews·Matthew J Page, Julian P T Higgins
Sep 8, 2016·The New England Journal of Medicine·Glenn J JaffeEric B Suhler
Oct 25, 2016·Ophthalmology·Quan Dong NguyenUNKNOWN Sirolimus study Assessing double-masKed Uveitis tReAtment (SAKURA) Study Group
Jun 28, 2017·Investigative Ophthalmology & Visual Science·Alastair K DennistonSunil K Srivastava

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Citations

Jul 30, 2020·BMJ Open Ophthalmology·Mohammad O TallouziJonathan M Mathers

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