The effector to memory transition of CD4 T cells.

Immunologic Research
K Kai McKinstrySusan L Swain

Abstract

The small number of antigen-specific memory CD4 T cells surviving long-term after antigen or pathogen challenge are often characterized by a surprising degree of phenotypic and functional heterogeneity. We here propose that the immune system has evolved to express this diversity in memory T-cell populations, in order to provide flexibility in recall responses, via a rapid transition from heterogeneous effector cells into correspondingly heterogeneous memory cells. Little attention has been paid to another important transition-from resting memory cell to re-activated effector. We would suggest that superior functional attributes of secondary effectors arising from memory CD4 T cells, as compared to primary effectors arising from naïve precursors, play an important and underappreciated role in protective secondary immune responses.

References

Nov 1, 1991·The Journal of Experimental Medicine·D Gray, P Matzinger
Oct 4, 1996·Science·J D AltmanM M Davis
May 23, 1998·Annual Review of Immunology·R W DuttonS L Swain
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·C A LondonA K Abbas
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P R RogersS L Swain
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D M Jelley-GibbsS L Swain
Dec 6, 2000·The Journal of Experimental Medicine·P SchaerliB Moser
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R MercadoE G Pamer
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Judith HarbertsonLinda M Bradley
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathryn E FouldsHao Shen
Mar 22, 2002·Nature Reviews. Immunology·David Gray
May 11, 2002·Nature Reviews. Immunology·Susan M KaechRaft Ahmed
May 23, 2002·Immunologic Research·Donna L Farber, Mojgan Ahmadzadeh
Oct 9, 2002·The Journal of Experimental Medicine·Eulogia RománSusan L Swain
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Linda S CauleyDavid L Woodland
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vladimir P BadovinacJohn T Harty
Sep 30, 2003·European Journal of Immunology·Matthias SchiemannDirk H Busch
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rob J De BoerAlan S Perelson
Dec 10, 2003·The Journal of Experimental Medicine·Robyn M KondrackLinda M Bradley
Dec 17, 2003·The Journal of Experimental Medicine·JiChu LiSusan L Swain
Sep 24, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Timothy J PowellRichard W Dutton
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·George Kassiotis, Brigitta Stockinger
Apr 14, 2005·Seminars in Immunology·Booki Min, William E Paul
Apr 14, 2005·Seminars in Immunology·Stephen C Jameson
Sep 9, 2005·The Journal of Experimental Medicine·Dawn M Jelley-GibbsSusan L Swain
Sep 24, 2005·Vaccine·Shahram Salek-Ardakani, Michael Croft
Oct 13, 2005·European Journal of Immunology·Adam W BingamanDonna L Farber
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason K WhitmireJ Lindsay Whitton
Mar 4, 2006·Science·Jason HatayeMarc K Jenkins
Mar 22, 2006·The Journal of Experimental Medicine·Megan MacLeodDavid Gray
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pejman SorooshNaoto Ishii
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Warren N D'Souza, Stephen M Hedrick
Jul 11, 2006·Immunological Reviews·Hans Dooms, Abul K Abbas
Jul 11, 2006·Immunological Reviews·Jennifer M RobertsonPhilippa Marrack

❮ Previous
Next ❯

Citations

Dec 4, 2008·Journal of Clinical Immunology·Tara M StruttSusan L Swain
Mar 26, 2008·Immunology and Cell Biology·Dawn M Jelley-GibbsSusan L Swain
Jan 24, 2012·Nature Reviews. Immunology·Susan L SwainTara M Strutt
Mar 16, 2011·The Journal of Experimental Medicine·Pejman SorooshMichael Croft
Aug 25, 2010·International Immunology·Ben YoungbloodRafi Ahmed
Dec 3, 2011·Current Opinion in HIV and AIDS·Ben YoungbloodRafi Ahmed
Sep 24, 2008·Retrovirology·Michael Bukrinsky
Jul 6, 2014·Tuberculosis·Marcela Henao-TamayoIan M Orme
Aug 7, 2009·European Journal of Immunology·Stephen M TodrykAdrian V S Hill
Mar 18, 2009·Immunological Reviews·Mercedes Rincón, Roger J Davis
Apr 26, 2012·European Journal of Immunology·Susanne KaeslerTilo Biedermann
Mar 25, 2010·Immunology·K Kai McKinstrySusan L Swain
Jul 20, 2010·Immunological Reviews·K Kai McKinstrySusan L Swain
Apr 13, 2018·PLoS Pathogens·Patrick YounanAlexander Bukreyev
Jan 29, 2010·Clinical and Vaccine Immunology : CVI·Marcela I Henao-TamayoIan M Orme
Jul 17, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eugene V Ravkov, Matthew A Williams
May 5, 2021·Advanced Biology·Sarah L BarronRóisín M Owens

❮ Previous
Next ❯

Related Concepts

Related Feeds