The effects and expression of Survivin and Aurora-b in laryngeal carcinoma

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
C H HuX S He

Abstract

Objective:The aim of this study is to investigate the relationship between the expression of Survivin and Aurora-b in laryngeal carcinoma and its clinical and pathological features, and to determine the possibility of Survivin and Aurora-b being a biomarker in laryngeal carcinoma diagnosis or being an predictor of overall survival (OS) in laryngeal carcinoma patients underwent surgical resection. Method:Eighty-six cases of laryngeal carcinoma tissues diagnosed by pathology were collected, and 86 cases of adjacent tissues and 22 cases of normal tissues were selected as control. The expression of Survivin and Aurora-b were detected by immunohistochemistry in laryngeal carcinoma, adjacent tissues and normal tissue. Result:Survivin and Aurora-b in laryngeal carcinoma were significantly higher than those in adjacent tissues and normal tissues (P<0.01). The expression of Survivin protein was correlated with clinicopathological features such as lymph node metastasis and recurrence (P<0.05), but it was not related to the pathological features such as age, sex, clinical stage and differentiation. The expression of Aurora-b was correlated with the pathological grade clinical stag (TNM stage) and recurrence in laryngeal carcinoma (P<0.05)...Continue Reading

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