PMID: 8967884Dec 1, 1995Paper

The effects and pharmacokinetics of rhG-CSF in patients with chronic renal failure

Artificial Organs
T AkizawaS Koshikawa

Abstract

The pharmacokinetics and effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on neutrophils and immunological function were studied in 10 patients with end-stage renal failure. A single dose and 2-week consecutive dosing of 50 micrograms/m2 of rhG-CSF were drip infused intravenously, and plasma rhG-CSF levels, peripheral blood cell counts, coagulation, and neutrophil and immunological functions were determined during treatment. The mean half-life of rhG-CSF in patients (2.47 +/- 0.64 h) was prolonged to about twice that of healthy subjects, and hemodialysis did not affect the pharmacokinetics. A marked increase in neutrophils and a slight increase in lymphocytes were observed with the single and consecutive administration of rhG-CSF, but no significant changes were noted in other leukocyte fractions and erythrocyte and platelet counts. The neutrophil alkaline phosphatase value increased significantly following rhG-CSF administration, and other neutrophil functions were also ameliorated in several patients with neutrophil dysfunction. In consecutive administration, however, mild bone pain and increased serum alkaline phosphatase were observed in about half the patients, but neither accumulation of rhG-CS...Continue Reading

References

Mar 1, 1990·American Journal of Hematology·M YamamotoY Maeda
Dec 1, 1983·The Journal of Experimental Medicine·D A Cantrell, K A Smith

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Citations

May 11, 2005·Kidney International·Bertrand L Jaber
Mar 23, 2006·Seminars in Dialysis·Orfeas LiangosBertrand L Jaber
Feb 21, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Y F LiJ J Kavanagh
Jan 17, 2012·British Journal of Clinical Pharmacology·David CzockHanna M Seidling
Feb 26, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Martina T MoglOlaf Guckelberger
Jun 20, 2003·British Journal of Clinical Pharmacology·E Niclas JonssonMats O Karlsson

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