The Effects of 1-Hz rTMS on Emotional Behavior and Dendritic Complexity of Mature and Newly Generated Dentate Gyrus Neurons in Male Mice

International Journal of Environmental Research and Public Health
Marco CambiaghiFortunato Battaglia

Abstract

Low-frequency repetitive transcranial magnetic stimulation (1-Hz rTMS) is a promising noninvasive tool for the treatment of depression. Hippocampal neuronal plasticity is thought to play a pivotal role in the pathophysiology of depressive disorders and the mechanism of action of antidepressant treatments. We investigated the effect of 1-Hz rTMS treatment on hippocampal dentate gyrus structural plasticity and related emotional behaviors modifications. Experimentally, adult male mice received either five days of 1-Hz rTMS or Sham stimulation. After stimulation, the mice underwent a battery of tests for anxiety-like and depression-like behaviors. We also tested the effect of treatment on mature and newly generated granule cell dendritic complexity. Our data showed that 1-Hz rTMS induced structural plasticity in mature granule cells, as evidenced by increased dendritic length and number of intersections. However, the stimulation did not increase the proliferation of the dentate gyrus progenitor cells. On the contrary, the stimulated mice showed increased dendritic complexity of newly generated neurons. Moreover, 1-Hz rTMS resulted in antidepressant-like effects in the tail suspension test, but it did not affect anxiety-like behavio...Continue Reading

References

Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y I ShelineM W Vannier
Jun 1, 1996·The Psychiatric Clinics of North America·M Fava, K G Davidson
Apr 15, 1999·Annual Review of Neuroscience·B S McEwen
Feb 17, 2001·Current Opinion in Neurobiology·H T Cline
May 2, 2001·Nature Reviews. Neuroscience·M L Wong, J Licinio
Jun 19, 2003·JAMA : the Journal of the American Medical Association·Ronald C KesslerUNKNOWN National Comorbidity Survey Replication
Nov 4, 2004·Biological Psychiatry·Craig A StockmeierGrazyna Rajkowska
Jun 9, 2005·Archives of General Psychiatry·Ronald C KesslerEllen E Walters
Apr 25, 2006·Biological Psychiatry·Ronald S Duman, Lisa M Monteggia
May 4, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tarique D PereraAndrew J Dwork
May 15, 2007·Current Opinion in Neurobiology·Jennifer Bourne, Kristen M Harris
Jan 5, 2008·Journal of Neurosurgery·Hiroki TodaAndres M Lozano
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jing-Wen WangRené Hen
Feb 21, 2008·Annual Review of Neuroscience·Jennifer N Bourne, Kristen M Harris
Sep 23, 2008·Experimental Neurology·David ReveszThorleif Thorlin
Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amelia J EischLinda S Overstreet-Wadiche
Apr 18, 2009·Developmental Neuroscience·Maya FrankfurtEitan Friedman
Oct 6, 2009·Drug Discovery Today. Therapeutic Strategies·Heath D SchmidtRonald S Duman
Jan 26, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·V Di LazzaroU Ziemann
Jun 10, 2010·Genes, Brain, and Behavior·K SakataS Jha
Aug 24, 2010·The European Journal of Neuroscience·Tonio HeideggerUlf Ziemann
Dec 17, 2010·Expert Review of Medical Devices·Paul B Fitzgerald, Zafiris J Daskalakis
Jan 27, 2011·Psychiatry and Clinical Neurosciences·Eiko UeyamaKazuhiro Shinosaki
Feb 18, 2016·Neural Plasticity·Hui QiaoXin-Ming Ma

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