PMID: 11903858Mar 21, 2002Paper

The effects of 1 week of REM sleep deprivation on parvalbumin and calbindin immunoreactive neurons in central visual pathways of kittens

Journal of Sleep Research
D HoganJames P Shaffery

Abstract

Many maturational processes in the brain are at high levels prenatally as well as neonatally before eye-opening, when extrinsic sensory stimulation is limited. During these periods of rapid brain development, a large percentage of time is spent in rapid eye movement (REM) sleep, a state characterized by high levels of endogenously produced brain activity. The abundance of REM sleep in early life and its ensuing decline to lower levels in adulthood strongly suggest that REM sleep constitutes an integral part of the activity-dependent processes that enable normal physiological and structural brain development. We examined the effect of REM sleep deprivation during the critical period for visual development on the development of two calcium-binding proteins that are associated with developmental synaptic plasticity and are found in the lateral geniculate nucleus (LGN) and visual cortex. In this study, REM sleep deprivation was carried out utilizing a computer-controlled, cage-shaking apparatus that successfully suppressed REM sleep. Body weight data suggested that this method of REM sleep deprivation produced less stress than the classical multiple-platform-over-water method. In REM sleep-deprived animals with normal binocular vis...Continue Reading

Citations

Apr 10, 2003·Progress in Neurobiology·Joel H Benington, Marcos G Frank
Nov 24, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·W F LiuUNKNOWN NIC/Q 2005 Physical Environment Exploratory Group
Feb 12, 2011·Infant and Child Development·Amanda R TarulloWilliam P Fifer
Jul 9, 2004·Medical Hypotheses·Georg Schulze
Aug 4, 2004·Clinics in Perinatology·Stanley N Graven
Apr 23, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Samira F OsteropLaszlo Vutskits
Feb 2, 2006·Pediatric Rehabilitation·T T Dang-VuP Maquet
Feb 13, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·James ShafferyRoseanne Armitage
Jan 1, 2013·ISRN Nephrology·Fabrizio Fabrizi
Mar 28, 2020·Journal of Neuroscience Research·Taylor WintlerLucia Peixoto
Apr 6, 2021·Current Sleep Medicine Reports·Marcos G Frank

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