The effects of 100% wild blueberry (Vaccinium angustifolium ) juice consumption on cardiometablic biomarkers: a randomized, placebo-controlled, crossover trial in adults with increased risk for type 2 diabetes

BMC Nutrition
K S StoteKatherine Gottschall-Pass

Abstract

Wild blueberries have a high content of polyphenols, but there is limited data evaluating their health benefits in adults at risk for type 2 diabetes. The objective of the study was to investigate whether consumption of 100% wild blueberry juice improves cardiometabolic biomarkers associated with type 2 diabetes risk. A single-blind, randomized, placebo-controlled, crossover design trial was conducted in which adults (women, n = 19, ages 39-64 y) at risk for type 2 diabetes consumed 240 mL of wild blueberry juice or a placebo beverage as part of their free-living diet for 7 days. Blood was collected to determine various biomarkers such as fasting plasma glucose, fasting serum insulin, surrogate markers of insulin sensitivity, triglycerides, inflammation (interleukin-6, interleukin-10, high-sensitivity C-reactive protein, tumor necrosis factor-alpha, serum amyloid A), adhesion molecules (soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1), oxidative stress (LDL-oxidation, total 8-isoprostanes), and nitric oxide. Endothelial function and blood pressure were also assessed. Wild blueberry juice consumption for 7 days produced no significant changes in glucose, insulin, insulin sensitivity, triglycerides...Continue Reading

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Citations

Mar 4, 2020·Annual Review of Food Science and Technology·Elvira Gonzalez de MejiaMary Ann Lila
Sep 19, 2019·Nutrition Reviews·Kacie K H Y HoJoLynne D Wightman
Apr 4, 2021·International Journal of Molecular Sciences·Rami S NajjarRafaela G Feresin
Jun 18, 2021·Nutrition Research·Marina Fernandes CarvalhoMaísa Silva
Aug 11, 2018·Journal of Agricultural and Food Chemistry·Xianli WuPamela R Pehrsson

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Methods Mentioned

BETA
hormone replacement therapy
biosensors

Clinical Trials Mentioned

NCT02139878

Software Mentioned

SAS

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