PMID: 9444943Jan 28, 1998Paper

The effects of 13-cis retinoic acid and interferon-alpha in chronic myelogenous leukemia cells in vivo in patients

Leukemia Research
H HandaH D Preisler

Abstract

The effects of the administration of a 3-day course of 13-cis retinoic acid in combination with interferon a [RA/IFN] on the leukemia cells was measured in vivo in 43 patients with chronic myelogenous leukemia. The administration of RA/IFN was associated with a significant fall in the white blood cell count of patients with chronic-phase disease and with a fall in the percentage S-phase cells in CML patients regardless of the stage of their leukemia. In two thirds of the patients studied the administration of RA/IFN was also associated with an increase in marrow apoptosis. The cytokine combination also suppressed bcl-2 and myc expression in a minority of patients and such expression appears to be associated with response to a treatment regimen which includes RA/IFN. These studies are the first to directly assess the effects of the combination of RA/IFN on chronic myelogenous leukemia cells in vivo in patients. These effects, if seen in other malignant diseases, could account for the therapeutic benefit which has been associated with the administration of this combination of biological agents to patients with malignant disease.

References

Oct 1, 1992·Leukemia Research·V GopalH Preisler
Oct 1, 1991·British Journal of Haematology·W Bollag
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S M LippmanI H Krakoff
Mar 17, 1993·Journal of the National Cancer Institute·S M LippmanI H Krakoff

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Citations

Jul 5, 2005·Expert Opinion on Investigational Drugs·S C Dixon, I N Arah
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R S DiPaolaW N Hait
May 14, 2011·The British Journal of Dermatology·A M NelsonD M Thiboutot

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