PMID: 1197576Oct 14, 1975Paper

The effects of 2,5-dimethoxy-4-methylamphetamine (DOM), 2,5-dimethoxy-4-ethylamphetamine (DOET), d-amphetamine, and cocaine in rats trained with mescaline as a discriminative stimulus

Psychopharmacologia
J C Winter

Abstract

The effects of mescaline (3,4,5-trimethoxyphenylethylamine), a hallucinogen, can function as a discriminative stimulus in appropriately trained rats. As a test of the hypothesis that those pharmacologic properties which distinguish hallucinogens and non-hallucinogens in man are reflected in distinctive stimuli in rats, the present experiments examined the effects of 2,5-dimethoxy-4-methylamphetamine (DOM), 2,5-dimethoxy-4-ethylamphetamine (DOET), d-amphetamine, and cocaine in rats trained with mescaline as a discriminative stimulus. Administration of a range of doses of DOM and DOET to subjects in which saline functioned as SD and mescaline as Sdelta revealed that a dose of 0.3 mg of either DOM or DOET was equivalent to the training dose of mescaline. When tested in rats in which mescaline served as SD, DOM and DOET were likewise found to mimic mescaline. In contrast, doses of d-amphetamine and cocaine (1 and 30 mg/kg, respectively) which were equivalent to the training dose of mescaline as Sdelta, did not result in responding appropriate for the mescaline condition when mescaline was trained as SD. When DOET (0.3 mg/kg) was substituted for saline as Sdelta, no evidence of discriminated responding was obtained in the course of ...Continue Reading

References

Sep 1, 1968·The American Journal of Psychiatry·S H SnyderH Weingartner
Sep 1, 1974·Pharmacology, Biochemistry, and Behavior·J T Huang, B T Ho
Feb 1, 1972·Archives of General Psychiatry·J D GriffithJ A Oates
Jul 1, 1974·Archives of General Psychiatry·S H SnyderC F Barfknecht
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Jun 25, 1966·Nature·L E Hollister, A J Friedhoff
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Citations

Jan 1, 1983·Journal of Psychosomatic Research·P Tyrer
Mar 1, 1981·Pharmacology, Biochemistry, and Behavior·R A GlennonR Young
Apr 1, 1982·Pharmacology, Biochemistry, and Behavior·R A GlennonJ A Rosecrans
Jan 22, 2013·ACS Chemical Neuroscience·James B Hanks, Javier González-Maeso
Nov 1, 1977·British Journal of Pharmacology·G D D'Mello, I P Stolerman
Jan 1, 1976·Annals of the New York Academy of Sciences·R J WyattJ C Gillin

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