The effects of 3,4-dihydro-8-(2-hydroxy-3-isopropylaminopropoxy)-3-nitroxy-2H-1-benzopyran (K-351) and its denitrated derivative on smooth muscle cells of the dog coronary artery

British Journal of Pharmacology
K Kou, H Suzuki

Abstract

1 Effects of 3,4-dihydro-8-(2-hydroxy-3-isopropylaminopropoxy)-3-nitroxy-2H-1-benzopyran (K-351) and its derivative, 3,4-dihydro-8-(2-hydroxy-3-isopropylaminopropoxy)-3-hydroxy-2H-1-benzopyran (K-351 (N-)) on the electrical and mechanical properties of smooth muscles of the dog coronary and mesenteric arteries were investigated, and the findings were compared with data obtained with nitroglycerin. 2 In both proximal and distal regions of the coronary arteries, K-351 and nitroglycerin reduced the resting tone and suppressed the contractions produced by high-potassium solution or by current passage to the same extent, with no remarkable change in the electrical properties of the smooth muscle membrane. 3 In the proximal regions of the descending coronary artery, low and high concentrations of noradrenaline (NA) produced relaxation and contraction of the muscle, respectively. In the distal region, NA consistently relaxed the muscle with concentrations up to 10(-5) M. In both regions, the contraction or relaxation was suppressed by phentolamine or propranolol, respectively. 4 K-351 suppressed the NA-induced contraction. K-351(N-) potentiated the NA-induced contraction and suppressed the relaxation, but these actions were weaker tha...Continue Reading

References

May 1, 1968·The Journal of Physiology·Y Abe, T Tomita
Jan 1, 1981·Physiological Reviews·P M VanhoutteR C Webb

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Citations

Mar 14, 1989·European Journal of Pharmacology·T HanedaS Onodera
Mar 17, 2001·Clinical and Experimental Pharmacology & Physiology·T ItomineM Sakanashi
Sep 1, 1994·British Journal of Clinical Pharmacology·A J BowmanG A Ford
Oct 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·W BoogerdD Moffie
Jun 1, 1987·British Journal of Pharmacology·K Noguchi, M Sakanashi

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