PMID: 6966764Mar 1, 1980Paper

The effects of 5-HT uptake- and MAO-inhibitors on L-5-HTP-induced excitation in rats

Naunyn-Schmiedeberg's Archives of Pharmacology
R OrtmannA Delini-Stula

Abstract

The behavioural syndrome caused by L-5-HTP in rats was used for the study of effects of selective 5-HT uptake inhibitors and inhibitors of MAO on central 5-HT receptors. A good correlation was found between the relative potencies of drugs in inhibiting the 5-HT uptake in the rat brain and in intensifying L-5-HTP-induced behavioural stimulation. The potentiation of the L-5-HTP syndrome by the MAO inhibitors correlated with the inhibition of the A- but not of the B-form of the brain monoamine oxidase. In rats treated with the maximally inhibiting dose of a 5-HT uptake inhibitor, MAO inhibitors were still able to increase the intensity of the L-5-HTP syndrome, while the combination of maximal doses of two 5-HT uptake inhibitors did not produce a more intense syndrome than that produced by one 5-HT uptake inhibitor alone. The L-5-HTP-induced behavioural syndrome in rats seems to afford an experimental model allowing the quantification and characterization of the interaction of drugs with serotonin metabolism in the brain.

References

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Citations

Jan 1, 1988·Journal of Neural Transmission·S TurkishA J Greenshaw
Jan 1, 1989·Life Sciences·D D TruongS Fahn
Apr 1, 1983·Pharmacology, Biochemistry, and Behavior·E MogilnickaA Delini-Stula
Nov 1, 1985·Pharmacology, Biochemistry, and Behavior·D L Sparks, N S Buckholtz
Jan 31, 2004·Pharmacology, Biochemistry, and Behavior·Connie Sánchez, Mads Kreilgaard
Feb 22, 2003·Il Farmaco·Candelaria C Sánchez-MateoLuz M Albertos
Feb 18, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ouissame Mnie-FilaliNasser Haddjeri
Jan 1, 1996·Fundamental & Clinical Pharmacology·M BourinP Deguiral
Jan 1, 1990·Annals of the New York Academy of Sciences·R W Fuller, D T Wong
May 20, 1999·Journal of Affective Disorders·O CuretB Scatton
Aug 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·P A Baumann, P C Waldmeier
Sep 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·P C Waldmeier
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·J Hyttel
Sep 6, 2013·Behavioural Brain Research·Robert HaberzettlMeredith A Fox
May 2, 2014·Behavioural Brain Research·Robert HaberzettlBettina Bert
Oct 18, 2016·Journal of Pharmacological and Toxicological Methods·David V GauvinTheodore J Baird
Feb 1, 1986·British Journal of Pharmacology·H Hallberg
Jan 1, 1991·Journal of Psychopharmacology·S L DickinsonB Gadie
Jan 1, 1985·Critical Reviews in Toxicology·P Gross
Oct 3, 1999·Journal of Clinical Psychopharmacology·P Popik
Aug 29, 1991·The New England Journal of Medicine·W Z PotterH Manji
Jan 1, 1985·Acta Pharmacologica Et Toxicologica·J Hyttel, J J Larsen

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