PMID: 8983029Jan 1, 1997Paper

The effects of 5-HT3 receptor antagonists on cognitive performance in aged monkeys

Neurobiology of Aging
A F ArnstenK J Stanhope

Abstract

The serotonin 5-HT3 receptor antagonists ondansetron and SEC-579 were tested over a wide dose range (0.000001-0.5 mg/kg, PO) for cognitive-enhancing effects in aged rhesus monkeys. Animals were tested on the following cognitive and motor tasks: 1) acquisition of a visual object discrimination; 2) reversal of a visual object discrimination; 3) the delayed response task, a spatial working memory task; and 4) a fine motor task. This study found enhanced acquisition of a visual object discrimination following very low doses (0.000001-0.00001 mg/kg, PO) of either 5-HT3 receptor antagonist. This finding replicates a previous study in marmosets. However, unlike the marmoset research, no reliable improvement was found on the reversal condition. Similarly, no improvement was observed on the delayed response or fine motor tasks. No side effects were observed at any dose, consistent with reports in both animals and humans. These results suggest that 5-HT3 receptor antagonists may be helpful in treating a subset of cognitive functions.

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Citations

Dec 3, 2011·Psychopharmacology·Alicia Izquierdo, J David Jentsch
Aug 18, 2001·Pharmacology, Biochemistry, and Behavior·H D UneS B Kasture
Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·Neeti N JainS B Kasture
Sep 1, 1997·Pharmacology, Biochemistry, and Behavior·A F Arnsten, J D Jentsch
Jan 22, 2000·Neuroscience and Biobehavioral Reviews·A Meneses
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·B KaltschmidtC Kaltschmidt
Oct 19, 2010·Expert Opinion on Investigational Drugs·Youhoon Chong, Hyunah Choo
Apr 2, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Maurice DyskenUNKNOWN Ondansetron Study Group
Oct 13, 2015·Progress in Neurobiology·Yukihiro OhnoMasashi Sasa
Aug 7, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Kristian Gaarn du JardinAlan L Pehrson
May 23, 2000·Annals of Medicine·M C BuhotL Segu
Oct 2, 2003·Expert Opinion on Investigational Drugs·Sheila A Doggrell, Suzanne Evans
Dec 20, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cécile BétryNasser Haddjeri
Feb 6, 2013·Pharmacology, Biochemistry, and Behavior·Arne MørkConnie Sanchez
Aug 1, 2012·Brain, Behavior and Evolution·Andrea Strasser, Judith M Burkart
Mar 8, 2018·The International Journal of Neuropsychopharmacology·Fenghua ChenJens R Nyengaard
Feb 9, 2008·Nursing & Health Sciences·Sandra L McGuireShu-Li Chen
Nov 18, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Fenghua ChenGregers Wegener
Feb 15, 2011·Pharmacology, Biochemistry, and Behavior·Alvin V TerryScott J Webster
Jan 18, 2022·The Journal of Physiological Sciences : JPS·Zeynab SayahiJavad Mirnajafi-Zadeh
Jul 7, 2012·Progress in Neurobiology·José Julio RodríguezAlexei Verkhratsky

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