The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Hannah Weinberg-WolfSteve W C Chang

Abstract

Psychiatric disorders, particularly depression and anxiety, are often associated with impaired serotonergic function. However, serotonergic interventions yield inconsistent effects on behavioral impairments. To better understand serotonin's role in these pathologies, we investigated the role of serotonin in a behavior frequently impaired in depression and anxiety, attention. In this study, we used a quantitative, repeated, within-subject, design to test how L-5-hydroxytryptophan (5-HTP), the immediate serotonin precursor, modulates central serotoninergic function and attention in macaques. We observed that intramuscular 5-HTP administration increased cisternal cerebrospinal fluid (CSF) 5-HTP and serotonin. In addition, individuals' baseline looking duration, during saline sessions, predicted the direction and magnitude in which 5-HTP modulated attention. We found that 5-HTP decreased looking duration in animals with high baseline attention, but increased looking duration in low baseline attention animals. Furthermore, individual differences in 5-HTP's effects were also reflected in how engaged individuals were in the task and how they allocated attention to salient facial features-the eyes and mouth-of stimulus animals. However...Continue Reading

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Citations

Feb 19, 2019·Wiley Interdisciplinary Reviews. Cognitive Science·Hannah Weinberg-Wolf, Steve W C Chang
Jun 21, 2018·American Journal of Primatology·Philip T PutnamKatalin M Gothard
Nov 14, 2020·Current Biology : CB·Fanny CazettesZachary F Mainen
Aug 11, 2020·Current Opinion in Neurobiology·Sara Rj Gilissen, Lutgarde Arckens

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