The effects of a cardioselective (metoprolol) and a nonselective (propranolol) beta-adrenergic blocker on the response to dynamic exercise in normal men

Circulation
J SklarA S Nies

Abstract

We compared the effects of a cardioselective beta-adrenergic blocking drug, metoprolol, with a nonselective beta-adrenergic blocker, propranolol, on the response of 10 normal men to dynamic treadmill exercise. The volunteers underwent a standard graded exercise test to exhaustion while receiving placebo; propranolol, 40 mg every 6 hours; propranolol, 80 mg every 6 hours; metoprolol, 50 mg every 6 hours; or metoprolol, 100 mg every 6 hours. The drugs were given in a double-blind fashion for 48 hours before exercise. Five days were allowed between successive drug administrations and the order of drug administration was randomized. Heart rate, arterial pressure, oxygen consumption, minute ventilation and CO2 production were monitored. Plasma drug concentrations were measured at the time of exercise. Judged by plasma levels, propranolol was about three times more potent than metoprolol in attenuating heart rate. Both drugs produced a wide variation in plasma levels after a given oral dose, and both drugs attenuated the systolic blood pressure response to exercise. Neither drug affected diastolic blood pressure or maximum oxygen consumption, maximum minute ventilation or the anaerobic threshold. We conclude that there is no evidence...Continue Reading

References

Aug 1, 1979·British Journal of Clinical Pharmacology·S B PearsonJ M Patrick
Jul 1, 1979·The American Journal of Cardiology·R A BruceL J Clarke
Dec 9, 1978·British Medical Journal·P D McSorley, D J Warren
Feb 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·T ReybrouckL Billiet
Jan 1, 1975·Acta Pharmacologica Et Toxicologica·G JohnssonL Sölvell
Jan 1, 1975·Acta Pharmacologica Et Toxicologica·B AbladC G Regårdh
Nov 1, 1965·The Journal of Clinical Investigation·S EpsteinE Braunwald
May 1, 1980·The Journal of Clinical Investigation·R D AaronsP B Molinoff

Citations

May 1, 1996·Clinical Cardiology·A J Camm, L Fei
Jan 1, 1986·European Journal of Clinical Pharmacology·R VandongenP Rogers
May 31, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Christian HöchtCarlos Alberto Taira
Jan 1, 1990·Pharmacology & Therapeutics·J McAinsh, J M Cruickshank
Aug 30, 2005·Journal of Pharmacological and Toxicological Methods·Christian HöchtCarlos Alberto Taira
Nov 1, 1984·Journal of the American College of Cardiology·W R HiattL D Horwitz
Apr 1, 1984·Journal of the American College of Cardiology·M TolinsG L Pierpont
Aug 1, 1987·Journal of the American College of Cardiology·J E AtwoodV Froelicher
Aug 1, 1991·British Journal of Clinical Pharmacology·L GullestadJ Kjekshus
Nov 1, 1993·Acta Physiologica Scandinavica·L GullestadO M Sejersted
Jun 1, 1985·British Journal of Sports Medicine·S N KoyalM H Ellestad
Jun 1, 1983·British Heart Journal·R S BextonA J Camm
Jul 1, 1985·British Heart Journal·N F GordonD P Myburgh
Oct 1, 2013·Journal of Hepatology·Phillip S Ge, Bruce A Runyon
Feb 20, 2003·Journal of Hepatology·Jaime BoschRoberto Groszmann
Mar 7, 2014·Expert Opinion on Drug Metabolism & Toxicology·Christian HöchtCarlos Alberto Taira
Jun 1, 1988·Scandinavian Journal of Clinical and Laboratory Investigation·T MäkiK Kontula
Oct 1, 1989·Scandinavian Journal of Clinical and Laboratory Investigation·L GullestadJ Kjekshus
Jan 16, 2016·Clinical Cardiology·Ashish ChaddhaBarry A Franklin
Jan 15, 1992·The American Journal of Cardiology·S BarvikH Vik-Mo
Sep 18, 1989·The American Journal of Medicine·O de DivitiisM Galderisi
Jan 1, 1985·Progress in Cardiovascular Diseases·H K Hammond, V Froelicher
Mar 1, 1983·The American Journal of Cardiology·L G Sherman, C S Liang
Jun 1, 1989·Journal of Clinical Pharmacology·P R KoweyW D Mason
Dec 1, 1984·The American Journal of Cardiology·P A AdesL D Horwitz
Aug 1, 1987·British Journal of Clinical Pharmacology·F WagnerH Roskamm
Nov 1, 1987·British Journal of Clinical Pharmacology·T H PringleR G Shanks
Mar 10, 2000·Cardiology Clinics·J S Strobel, G N Kay
Apr 26, 1985·The American Journal of Cardiology·W M SavinW L Haskell
Nov 14, 2002·American Journal of Ophthalmology·Paul J Lama
Jan 13, 2015·Steroids·Figueroa-Valverde LauroSarabia Alcocer Betty
Jul 1, 1985·The Physician and Sportsmedicine·J H WilmoreA R Morton
May 20, 2017·Pediatric Cardiology·Brandon D MorricalNathaniel W Taggart
May 12, 1998·The American Journal of Physiology·D K RohrerD Bernstein
Oct 28, 1998·Medicine and Science in Sports and Exercise·P Orbach, D T Lowenthal
Nov 28, 2008·Journal of Applied Physiology·Megan N HawkinsPeter B Raven
Nov 26, 1999·Alimentary Pharmacology & Therapeutics·M SchepkeT Sauerbruch

Related Concepts

Diastolic Blood Pressure
Pulse Rate
Hemodynamics
Betalok
Oxygen Consumption
Propanolamines
Rexigen

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.