The Effects of a Crosslinked, Modified Hyaluronic Acid (xCMHA-S) Gel on Equine Tendon Healing

Veterinary Surgery : VS
Henry W JannBrenda Mann

Abstract

To assess the effects of a crosslinked, modified hyaluronic acid (xCMHA-S) gel on equine tendon healing using an in vivo surgical model. In vivo experimental study. Adult horses (n = 5). Full thickness bilateral forelimb window tenectomies were surgically created in both forelimb superficial digital flexor tendons and xCMHA-S gel was implanted intraoperatively into the right forelimb lesion of each horse whereas the left forelimb served as the untreated control. Healing was monitored by serial ultrasound examinations every 14 days over the course of the 84 day study. In addition, gross pathology, scanning electron microscopy for fiber diameter, and histological scoring were completed on tendon samples harvested after euthanasia at 84 days. Ultrasound assessment demonstrated a significant decrease in mean lesion size of treated (0%) compared to control (30%) tendons at 84 days. Mean (±SD) cumulative histologic tendon scores for control tendons (17.7 ± 2.7) were significantly higher than treated tendons (13.6 ± 1.9), indicating less advanced healing in the control group. Tendon cell density was increased and neovascularization, intensity of inflammation, and uniformity of fiber diameter were increased in control compared to treat...Continue Reading

References

Nov 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L HagbergB Gerdin
Jul 1, 1990·Veterinary Surgery : VS·A L BertoneR W Norrdin
Apr 20, 1985·Journal of Molecular Biology·E MoslerM H Koch
Jul 1, 1997·Journal of Internal Medicine·J R FraserU B Laurent
Jul 1, 1997·Journal of Internal Medicine·B P Toole
Mar 21, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·R K SmithD Heinegård
Dec 9, 1998·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·J A IoconoH Paul
Oct 19, 2000·Equine Veterinary Journal·B A DowlingR K Smith
Oct 18, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Linda A DahlgrenAlan J Nixon
May 24, 2007·Tissue Engineering·Richard D PriceHarshad A Navsaria
Oct 10, 2007·Veterinary Research Communications·A CrovaceE Francioso
Aug 19, 2007·International Journal of Experimental Pathology·Peter D CleggRoger K Smith
Nov 7, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yanchun LiuGlenn D Prestwich
Jul 3, 2008·American Journal of Veterinary Research·Alan J NixonDaniel L Ward
Dec 25, 2008·Expert Review of Medical Devices·Jimin ChenMinghao Zheng
Jan 1, 2008·Organogenesis·Glenn D Prestwich
Jan 29, 2011·Stem Cell Research & Therapy·Ashlee E WattsAlan J Nixon
Dec 20, 2012·International Journal of Cell Biology·Thomas LawyerBrenda K Mann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.