The effects of a novel adjuvant complex/Eimeria profilin vaccine on the intestinal host immune response against live E. acervulina challenge infection.

Vaccine
Sung-Hyen LeePaul Dominowski

Abstract

The effects of a novel adjuvant composed of Quil A, cholesterol, dimethyl dioctadecyl ammonium bromide, and Carbopol (QCDC) on protective immunity against avian coccidiosis following immunization with an Eimeria recombinant protein were determined. Broiler chickens were subcutaneously immunized with isotonic saline (control), Eimeria recombinant profilin alone, or profilin emulsified with QCDC at 1 and 7 days post-hatch, and orally challenged with live Eimeria acervulina at 7 days following the last immunization. Body weight gains, gut lesion scores, fecal oocyst outputs, profilin serum antibody titers, lymphocyte proliferation, and intestinal cytokine transcript levels were assessed as measures of protective immunity. Chickens immunized with profilin plus QCDC showed increased body weight gains and decreased intestinal lesion scores compared with the profilin only or control groups. However, no differences were found in fecal oocyst shedding among the three groups. Profilin serum antibody titers and antigen-induced peripheral blood lymphocyte proliferation in the profilin/QCDC group were higher compared with the profilin only and control groups. Finally, while immunization with profilin alone or profilin plus QCDC uniformly in...Continue Reading

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Citations

Jun 24, 2014·General and Comparative Endocrinology·Elin SildPeeter Hõrak
Apr 21, 2012·Avian Pathology : Journal of the W.V.P.A·M W Shirley, H S Lillehoj
Feb 22, 2011·Comparative Immunology, Microbiology and Infectious Diseases·Sung Hyen LeeWongi Min
Nov 10, 2015·Experimental Parasitology·Florencia Celeste MansillaAlejandra Victoria Capozzo
Apr 16, 2013·Developmental and Comparative Immunology·Wongi MinHyun S Lillehoj
Feb 28, 2019·Frontiers in Veterinary Science·Valeria A SanderMarina Clemente

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Methods Mentioned

BETA
electrophoresis
ELISA

Software Mentioned

gene
SPSS

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