PMID: 9525295Apr 3, 1998Paper

The effects of a specific tachykinin receptor antagonist FK-224 on ozone-induced airway hyperresponsiveness and inflammation

Respirology : Official Journal of the Asian Pacific Society of Respirology
H AizawaN Hara

Abstract

We have demonstrated previously that tachykinin depletion by capsaicin prevented the ozone-induced airway hyperresponsiveness and the bronchial wall oedema in guinea pigs. To further clarify the role of neurogenic inflammation in ozone-induced airway hyperresponsiveness, we investigated the effects of a specific tachykinin receptor antagonist (FK-224) in guinea pigs. Animals were anaesthetized, tracheostomized and mechanically ventilated. Total pulmonary resistance (RL) was calculated from transpulmonary pressure and box flow in a plethysmograph. Airway responsiveness was assessed by determining the provocative concentration of histamine aerosol that increased RL to twice the baseline value (PC200). Animals were injected with either FK-224 (10 mg/kg, dissolved in 0.2 mL/kg DMSO) or vehicle (0.2 mL/kg DMSO) intravenously, then pre-ozone PC200 was determined. Following this measurement, animals were exposed to 3 ppm ozone for 60 min. Immediately after exposure, the histamine dose response curve was evaluated again. Bronchoalveolar lavage (BAL) was performed in animals treated with FK-224 or vehicle. In animals treated with vehicle, ozone exposure caused significant decrease in PC200 and moderate increase in neutrophils in BAL flu...Continue Reading

References

Jul 1, 1992·The American Review of Respiratory Disease·E UmenoS Nishima
Dec 1, 1992·The American Review of Respiratory Disease·H InoueT Ikeda
Jul 1, 1992·The American Review of Respiratory Disease·D A KnightP J Thompson
Jul 1, 1987·The American Review of Respiratory Disease·J E ThompsonD Sheppard
Jun 1, 1988·Journal of Applied Physiology·D B JacobyJ A Nadel
Jan 1, 1988·British Journal of Pharmacology·H AizawaM Tomooka
Oct 1, 1988·The American Review of Respiratory Disease·K BarnettS C Lazarus
Mar 1, 1985·Journal of Applied Physiology·N A FlavahanP M Vanhoutte
Apr 1, 1985·The American Review of Respiratory Disease·L A LaitinenT Haahtela
Feb 1, 1983·Pain·M Fitzgerald
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J M LundbergK Folkers
Dec 1, 1982·Acta Physiologica Scandinavica·J M Lundberg, A Saria
Aug 12, 1983·Biochemical and Biophysical Research Communications·M J HoltzmanE J Goetzl
Aug 1, 1984·The American Review of Respiratory Disease·P M O'ByrneM J Holtzman
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·H KotoN Hara
Jun 1, 1993·The American Review of Respiratory Disease·P H JarreauI Macquin-Mavier
Feb 1, 1958·The American Journal of Physiology·M O AMDUR, J MEAD

❮ Previous
Next ❯

Citations

Dec 28, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·H AizawaN Hara
Jul 21, 2001·American Journal of Respiratory and Critical Care Medicine·R M GrahamG W Hoyle
Feb 11, 2005·Experimental Lung Research·Masaru NishitsujiShinji Nakao
Jun 3, 2011·International Journal of Toxicology·Sheela SharmaVernon E Steele

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Respiratory and Critical Care Medicine
H KotoN Hara
Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
M MatsushitaK Wakitani
© 2022 Meta ULC. All rights reserved