The effects of A1 and A2A adenosine receptor agonists on kainic acid excitotoxicity in the guinea pig cochlea

Neuroscience Letters
Keiji TabuchiAkira Hara

Abstract

The present study aimed to clarify the protective effect of adenosine receptors against the excitotoxicity of cochlear afferent dendrites. The effects of 2-chloro-N6-cyclopentyladenosine (CCPA), an A1 adenosine receptor agonist, and 5'-N-cyclopropyl-carboxamidoadenosine (CPCA), an A2A adenosine receptor agonist, on cochlear excitotoxicity induced by kainic acid (KA) were examined using guinea pigs. KA was applied to the round window membrane at a concentration of 10mM for 30 min. CCPA or CPCA was given at the onset of KA application. KA morphologically induced the swelling of cochlear afferent dendrites and significantly elevated the threshold of the compound action potential (CAP) of the cochlea. CCPA inhibited the KA-induced CAP threshold shift and swelling of the cochlear afferent dendrites. However, CPCA did not affect cochlear excitotoxicity induced by KA. The results suggest that adenosine A1 receptor activation could prevent the excitotoxicity of cochlear afferent dendrites.

References

Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L O Trussell, M B Jackson
Mar 1, 1997·Hearing Research·M S FordV Ramkumar
May 2, 2000·The Journal of the Acoustical Society of America·H SunX Y Zheng
Jun 8, 2000·Annals of the New York Academy of Sciences·X Y ZhengD Henderson
Sep 30, 2000·Brain Research. Brain Research Reviews·A de MendonçaJ A Ribeiro
Oct 10, 2002·Hearing Research·Keiji TabuchiJun Kusakari
Apr 15, 2004·Biochemical Pharmacology·Craig A WhitworthLeonard P Rybak
Jul 24, 2008·The Tohoku Journal of Experimental Medicine·Shuhei SakaiAkira Hara

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Citations

Dec 28, 2019·Translational Vision Science & Technology·Yan GuoSteven L Bernstein
Jun 21, 2019·International Journal of Molecular Sciences·László KölesTibor Zelles

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