PMID: 8473532Apr 1, 1993Paper

The effects of Acacia arabica gum on the in vitro growth and protease activities of periodontopathic bacteria

Journal of Clinical Periodontology
D T ClarkG F Tinsley

Abstract

The antibacterial activity of acacia gum was assessed using fresh isolates and reference strains of Actinobacillus actinomycetemcomitans, Capnocytophaga spp., Porphyromonas gingivalis, Prevotella intermedia and Treponema denticola. A fine aqueous suspension of gum was produced by sonication and then a soluble fraction isolated by centrifugation and membrane filtration. These preparations were incorporated into columbia agar at doubling concentrations. Growth of P. gingivalis and P. intermedia cultures on the agar was inhibited by whole gum sonicate at concentrations of 0.5-1.0% w/v. Both species showed reduced susceptibility when horse blood was present in the agar. The gum soluble fraction did not inhibit growth of any bacterial culture. The effect of acacia on bacterial proteases was examined with cell sonicates from log phase broth cultures. Enzyme activities were determined by fluorimetric assay with various synthetic peptide substrates. Most protease activities reduced in the presence of 0.5% w/v gum sonicate, with the trypsin-like activities of P. gingivalis and P. intermedia proving most sensitive. The gum soluble fraction was nearly always less inhibitory than the sonicate. The action of acacia gum against suspected per...Continue Reading

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Citations

Jun 19, 2014·Expert Opinion on Drug Delivery·Wael M SamyNazik A Elgindy
Feb 3, 2016·International Journal of Biological Macromolecules·Fatma BouazizSemia Ellouz Chaabouni
Jan 6, 2016·ACS Applied Materials & Interfaces·Leming SunMingjun Zhang
Nov 27, 2007·Archives of Oral Biology·T OnishiT Ooshima
Oct 1, 2013·International Journal of Pharmaceutics·Baljit SinghAbhishek Dhiman
Sep 1, 1995·Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung·D EhlersP Toffel-Nadolny
Jan 10, 2009·Der Pathologe·A KrämerK Neben
Feb 23, 2008·Journal of the American Society for Mass Spectrometry·Gabriella NagyAmy V Walker
Jan 18, 2014·Der Radiologe·H LöfflerA Krämer
Aug 28, 2020·Periodontology 2000·Isabelle Laleman, Wim Teughels
May 25, 2018·International Journal of Food Sciences and Nutrition·María Gretel Michel-BarbaMarisela González-Ávila

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