The effects of acetaldehyde and disulfiram on albumin synthesis in the isolated perfused rabbit liver

Alcoholism, Clinical and Experimental Research
M A RothschildJ Mongelli

Abstract

Acetaldehyde infusions inhibit albumin synthesis in the liver from fed donors but not in the livers from fasted donors. The inhibition of acetaldehyde metabolism with 4-MP and disulfiram reverses this finding, suggesting that acetaldehyde per se is not the toxic agent. Disulfiram stimulates albumin synthesis in livers from fasted donors, and the presence of acetaldehyde does not prevent this process. The effects of ethanol infusions cannot be explained as due to the presence of acetaldehyde; some intermediate metabolic step may be the basis of the inhibition of albumin production and polysome disaggregation in the presence of ethanol.

References

Jun 22, 1978·Biochimica Et Biophysica Acta·W LevinsonJ Jackson
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D Shields, G Blobel
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Aug 1, 1964·The Biochemical Journal·A J MunroA Korner
Nov 8, 1965·Biochimica Et Biophysica Acta·A Fleck, D Begg
Aug 1, 1956·Archives of Biochemistry and Biophysics·K KECK
Sep 1, 1958·The Journal of Clinical Investigation·M A ROTHSCHILDH L McGEE
Nov 1, 1963·The Biochemical Journal·A S MCFARLANE

❮ Previous
Next ❯

Citations

Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·M A RothschildB Martin
May 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H OrregoL M Blendis
Jan 1, 1987·Annals of the New York Academy of Sciences·M A RothschildS S Schreiber
Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M A RothschildS S Schreiber
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·M A RothschildS S Schreiber

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.