The effects of acetazolamide on arterial pressure variability during REM sleep in the rat

Physiology & Behavior
M SoneS Sone

Abstract

During rapid eye movement (REM) sleep, the arterial pressure (AP) undergoes large fluctuations in the rat, cat, and other mammals, including humans, and it has been suggested that this effect originates in the forebrain. In addition, acetazolamide (ACTZ), a carbonic anhydrase inhibitor, is known to be effective in the treatment of central sleep apnea or epilepsy. The aim of the present study was to analyze the effects of ACTZ on EEG theta rhythm and AP variability during REM sleep in rats. Treatment consisted of intraperitoneal injection of 5 mg of ACTZ in 0.5 mL of saline (n = 6) or 0.5 mL of vehicle alone (n = 6). We then recorded and analyzed the mean AP (MAP) variations during different sleep phases, using a telemetric system. Our results show: 1) Significant decreases in the coefficient of variation of MAP, in the very-low frequency (0.025 - 0.225 Hz) component of the power spectral density of the AP and in theta frequency in the electroencephalogram, were seen in the ACTZ-treated group during REM sleep compared with controls, whereas no significant difference was found between the two groups in non-REM sleep. There was no significant difference in sleep duration, average MAP, and heart rate between the groups. Our data su...Continue Reading

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Citations

Feb 7, 2002·Trends in Pharmacological Sciences·Miao-Kun Sun, Daniel L Alkon
Jan 3, 2013·Neurotoxicology and Teratology·Jiye WangWenjing Luo
Sep 21, 2010·Brain Research Bulletin·Jolanta Orzeł-GryglewskaEdyta Jurkowlaniec
Apr 27, 2002·Journal of Neurophysiology·Miao-Kun Sun, Daniel L Alkon

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