The effects of acute and chronic administration of phosphatidylserine on cell proliferation and survival in the dentate gyrus of adult and middle-aged rats

Brain Research
Heloisa MaragnoLuiz Fernando Takase

Abstract

Phosphatidylserine (PS) is an acidic phospholipid that is widely used as an alternative and/or complementary treatment of cognitive impairments. We hypothesize that these changes may be attributable, at least in part, to alterations in hippocampal neurogenesis. The aim of the present study was to investigate the effects of acute and chronic PS administration on hippocampal cell proliferation and survival in adult (5 months old) and middle-aged (12 months old) male Wistar rats. PS was injected daily (50mg/kg, i.p.) during 7 days (acute experiment) or 21 days (chronic experiment). To label newly generated cells, rats received a single BrdU injection (200mg/kg, i.p.) one day before PS treatment. The object recognition test was performed, and the rats were perfused. The brains were removed and processed with immunohistochemistry techniques for Ki-67 (cell proliferation) and BrdU (cell survival). The acute and chronic regimens were unable to promote cognitive improvement in either age group in the object recognition test. The analysis of cell proliferation showed a significant increase in the number of Ki-67-positive cells after acute and chronic PS administration in both age groups. The analysis of cell survival showed that acute a...Continue Reading

References

Mar 25, 1976·Nature·A BruniE Boarato
Nov 5, 1990·Brain Research·J D Schaechter, R J Wurtman
May 1, 1991·Neurology·T H CrookD C Massari
Jan 1, 1986·Psychopharmacology·A ZanottiG Toffano
Nov 1, 1988·Behavioural Brain Research·A Ennaceur, J Delacour
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jun 20, 1972·Biochimica Et Biophysica Acta·W C BreckenridgeI G Morgan
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D S HeronD Samuel
Jan 1, 1981·Neurobiology of Aging·F DragoU Scapagnini
May 14, 1999·Trends in Cognitive Sciences·E GouldT J Shors
Nov 5, 1999·Physiology & Behavior·F T ClaroR Frussa-Filho
Jul 13, 2000·Molecular Psychiatry·B L JacobsF H Gage
Sep 12, 2000·European Journal of Pharmacology·C S AlvesM A Vital
Oct 2, 2001·Brain Research·K MizoguchiT Tabira
Oct 29, 2002·Brain, Behavior, and Immunity·Barry L Jacobs
Apr 8, 2003·The Journal of Physiology·Ruben Guzmán-MarínDennis McGinty
Apr 30, 2003·The Journal of Comparative Neurology·Alexandre G DayerHeather A Cameron
Jul 3, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica E Malberg, Ronald S Duman
Jun 15, 2004·Nature Neuroscience·Günter U HöglingerEtienne C Hirsch
Jul 28, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·João C CastilhoMaria A B F Vital
Feb 19, 2005·Neurobiology of Aging·Paul MohapelOlle Lindvall
Aug 17, 2005·Neurobiology of Learning and Memory·Ekrem DereMaria A De Souza Silva
Apr 21, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Flavia T ClaroRegina H Silva
Sep 27, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Naoko KanekoKazunobu Sawamoto
Dec 13, 2006·Brain Research·Casimir A FornalBarry L Jacobs
Jan 24, 2007·Neuroscience Letters·Barbara S BeltzDavid C Sandeman
Sep 29, 2007·Journal of Molecular Neuroscience : MN·Mingquan GuoHee-Yong Kim
May 6, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nachum Vaisman, Dori Pelled
Jun 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Chengwei HeJing X Kang
Aug 3, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bombi LeeDae-Hyun Hahm

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis