The effects of acute and sustained cannabidiol dosing for seven days on the haemodynamics in healthy men: A randomised controlled trial.

British Journal of Clinical Pharmacology
Salahaden R SultanTimothy J England

Abstract

In vivo studies show that cannabidiol (CBD) acutely reduces blood pressure (BP) in men. The aim of this study was to assess the effects of repeated CBD dosing on haemodynamics. Twenty-six healthy males were given CBD (600 mg) or placebo orally for seven days in a randomised, placebo-controlled, double-blind, parallel study (n = 13/group). Cardiovascular parameters were assessed at rest and in response to isometric exercise after acute and repeated dosing using Finometer®, Vicorder® and Duplex ultrasound. Compared to placebo, CBD significantly reduced resting mean arterial pressure (P = .04, two-way ANOVA, mean difference (MD) -2 mmHg, 95% CI -3.6 to -0.3) after acute dosing, but not after repeated dosing. In response to stress, volunteers who had taken CBD had lower systolic BP after acute (P = .001, two-way ANOVA, MD -6 mmHg, 95% CI -10 to -1) and repeated (P = .02, two-way ANOVA, MD -5.7 mmHg, 95% CI -10 to -1) dosing. Seven days of CBD increased internal carotid artery diameter (MD +0.55 mm, P = .01). Within the CBD group, repeated dosing reduced arterial stiffness by day 7 (pulse wave velocity; MD -0.44 m/s, P = .05) and improved endothelial function (flow mediation dilatation, MD +3.5%, P = .02, n = 6 per group), compared ...Continue Reading

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Citations

Apr 10, 2020·Expert Opinion on Drug Metabolism & Toxicology·Rafael G Dos SantosAntônio W Zuardi
Jul 18, 2020·Journal of Dietary Supplements·Elnaz Karimian AzariAnnalouise O'Connor
Oct 1, 2020·International Journal of Molecular Sciences·Olga SadowskaHanna Kozłowska
Sep 18, 2020·International Journal of Molecular Sciences·Aleksandra Kicman, Marek Toczek
Nov 23, 2020·Psychopharmacology·Stevie C BritchSharon L Walsh
Feb 23, 2021·Cannabis and Cannabinoid Research·Saoirse E O'SullivanSteven R Laviolette

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