The effects of acute bleeding on acid-base balance erythropoietin (Ep) production and in vivo P50 in the rat

British Journal of Haematology
M E MillerN McGilvray


The mechanism of erythropoietin (Ep) production after acute haemorrhage has been thought to be due to a reduction in blood volume and tissue perfusion leading to tissue hypoxia. In the present study we have evaluated the effect of acute haemorrhage in the rat on the acid-base status, the red cell affinity for oxygen in vivo, and Ep production. Within a few hours after acute blood loss there was a respiratory alkalosis with an increase in blood pH, a decrease in pCO2 and an increase in the red cell affinity of Hb for oxygen in vivo that was temporally related to an increase in Ep production. Within 24 h after the acute haemorrhage, the blood pH AND PCO2, red cell affinity for oxygen in vivo, and Ep level returned towards normal. The decrease in in vivo red cell affinity for oxygen was associated with an increase in red cell 2,3-DPG levels and a decrease in Ep production.


Apr 5, 1973·The New England Journal of Medicine·M E MillerF Stohlman
Jul 20, 1972·The New England Journal of Medicine·M J Edwards, B Canon
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·J W Eaton, G J Brewer
Nov 1, 1966·The American Journal of Medicine·A S Keitt
Jul 23, 1970·The New England Journal of Medicine·J TorranceC A Finch
May 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·R ShadduckF Stohlman
Aug 1, 1968·The Journal of Clinical Investigation·M J EdwardsJ Metcalfe
Oct 1, 1969·Journal of Applied Physiology·R D Hamstra, M H Block
Apr 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Kraml
Jan 1, 1967·Scandinavian Journal of Clinical and Laboratory Investigation·R MulhausenK Kjeldsen
Jun 1, 1954·Proceedings of the Society for Experimental Biology and Medicine·A S GORDONH H FREEDMAN
Oct 1, 1954·The Journal of Clinical Investigation·A C KENNEDY, D J VALTIS
May 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·R C CRAFTS, H A MEINEKE
Feb 1, 1960·Annals of Internal Medicine·T RODMANM K PURCELL
Apr 1, 1927·The Journal of Clinical Investigation·D W Richards, M L Strauss

❮ Previous
Next ❯


Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·T KlausenN V Olsen
Mar 15, 1990·Mechanisms of Ageing and Development·K Spodaryk
Jan 1, 1984·Comparative Biochemistry and Physiology. A, Comparative Physiology·T SuzukiM Suzuki
Sep 1, 1993·Journal of Cardiac Surgery·R E HelmK H Krieger
May 1, 1980·British Journal of Haematology·A J ErslevR Silver
Feb 1, 1981·Psychological Medicine·J H LazarusG Crockett
Sep 8, 2017·American Journal of Physiology. Renal Physiology·Seham RabadiMarta Christov

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.