The effects of acutely administered analgesics on the turnover of noradrenaline and dopamine in various regions of the rat brain

British Journal of Pharmacology
M F Sugrue

Abstract

1 Noradrenaline and dopamine turnover rates were determined following blockade of synthesis by alpha-methyl-p-tyrosine. Morphine, pentazocine and methadone had no effect on steady state levels or on turnover of noradrenaline in whole brain and in the hypothalamus. Although morphine was without action on medulla-pons noradrenaline steady state levels, a drug-induced increase in turnover rate was observed which was antagonized by pretreatment with naloxone (5 mg/kg). Pentazocine and methadone failed to alter either the steady state level of noradrenaline in the medulla-pons or its turnover rate.2 Morphine accelerated the decline in striatal alpha-methyl-m-tyramine levels following subcutaneous injection of alpha-methyl-m-tyrosine 18 h previously.3 All three drugs increased the turnover of dopamine in whole brain and corpus striatum although the striatal effect was prevented by naloxone pretreatment. The minimum doses of morphine, pentazocine and methadone required to elicit a significant effect on striatal dopamine turnover were 10 mg/kg, 30 mg/kg and 10 mg/kg respectively.4 The possibility of a dopaminergic involvement in the antinociceptive effect of analgesics is discussed.

References

Mar 1, 1969·European Journal of Pharmacology·L M GunneK Fuxe
Dec 1, 1969·The Journal of Pharmacy and Pharmacology·Y P Vedernikov, I I Afrikanov
Jul 1, 1972·The Journal of Pharmacy and Pharmacology·R L Dorris, P A Shore
Aug 1, 1972·Journal of Neurochemistry·H A SasameG L Gessa
Mar 9, 1973·Science·C B Pert, S H Snyder
May 1, 1973·European Journal of Pharmacology·L Ahtee, I Kääriäinen
Nov 1, 1973·European Journal of Pharmacology·P WandK H Sontag
Jul 1, 1972·European Journal of Pharmacology·K Kuschinsky, O Hornykiewicz
Jan 1, 1970·European Journal of Pharmacology·R SamaninL Valzelli
Dec 1, 1954·Proceedings of the Society for Experimental Biology and Medicine·J A SCHNEIDER

Citations

Jun 6, 1977·Psychopharmacology·Z Dunai-Kovács, J I Székely
Jan 1, 1985·Psychopharmacology·S K WooH H Loh
Jan 1, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·H MontelF Weber
Jan 1, 1979·Journal of Neural Transmission·P Moleman, J Bruinvels
Mar 15, 1983·Experientia·H R OlpeM W Steinmann
Dec 1, 1974·European Journal of Pharmacology·I Goodlet, M F Sugrue
Sep 1, 1976·European Journal of Pharmacology·J P GreenP I Szilagyi
Apr 1, 1978·European Journal of Pharmacology·P Slater, C Blundell
Dec 1, 1978·Neuropharmacology·P W DettmarD S Walter
Aug 1, 1992·Pharmacology, Biochemistry, and Behavior·K J SufkaR A Hughes
Aug 1, 1979·Behavioral and Neural Biology·L L Hernández, J B Appel
Jan 1, 1978·Drug Metabolism Reviews·T T Chau-Pham
Jan 1, 1987·Acta Anaesthesiologica Scandinavica. Supplementum·R D LobatoA Gozalo
Jan 1, 1979·Journal of Neuroscience Research·A W Crossley, P Slater
Sep 18, 1975·Nature·P R MyersW Shain

Related Concepts

Antinociceptive Agents
Metazoa
Brain
Lentiform Nucleus Structure
Intropin
Organum Vasculosum Laminae Terminalis
Medulla Oblongata
Physeptone
Morphine Sulfate (2: 1), Pentahydrate
Norepinephrine, (+, -)-Isomer

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