The effects of adjuvant experimental radioimmunotherapy and hyperthermic intraperitoneal chemotherapy on intestinal and abdominal healing after cytoreductive surgery for peritoneal carcinomatosis in the rat

Annals of Surgical Oncology
F AartsT Hendriks

Abstract

Cytoreductive surgery (CS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) results in limited survival benefit and high morbidity and mortality rates in patients with peritoneal carcinomatosis (PC). Radioimmunotherapy (RIT) after CS of experimental PC has been shown to increase survival and compare favorably to HIPEC. The effects of RIT and HIPEC on wound healing after CS need to be determined. PC was induced by intraperitoneal inoculation of CC-531 colon carcinoma cells in Wag/Rij rats. Animals were subjected to CS and anastomotic construction only or followed by RIT or HIPEC. RIT consisted of 74 MBq (177)lutetium-labeled anti-CC531 antibody MG1. HIPEC was performed by a closed abdominal perfusion technique using mitomycin-C during 60 minutes. Anastomotic and abdominal wall strength measurements were performed 3 and 5 days after surgery. At day 5, bursting pressure in ileum and colon anastomoses in the CS + HIPEC group, but not in the CS + RIT group, was lower (P < .01) than in the CS group. In the CS group, the colonic bursting site was more often outside the true anastomotic area (8 of 12 animals) than in the CS + HIPEC (1 of 12) and CS + RIT (5 of 12) groups. Abdominal wall strength in the CS + HIPEC group was...Continue Reading

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Citations

Apr 6, 2013·Immunotherapy·Christof Seidl, Markus Essler
May 12, 2009·Annals of Surgical Oncology·Gabie M de JongOtto C Boerman
Nov 17, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lore SantoroJean-Pierre Pouget
Oct 20, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Vincent BoudousqJean-Pierre Pouget
Nov 11, 2009·International Journal of Colorectal Disease·Wieland RaueJens Hartmann
Oct 9, 2013·Annals of Surgical Oncology·Francis S W ZihCarol J Swallow
Jul 13, 2013·Cancer Biotherapy & Radiopharmaceuticals·Maneesh JainSurinder K Batra
Aug 11, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·W CeelenP Pattyn
Feb 19, 2009·The British Journal of Surgery·G M de JongT Hendriks
Nov 19, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Martine C M WillemsJ Adam van der Vliet
Oct 15, 2013·Journal of Surgical Oncology·Félix GremonprezWim Ceelen
Jan 15, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Johanna Verhulst
Aug 28, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Todd M TuttleJane Y C Hui
Jul 25, 2017·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·F StrullerS Beckert
Sep 20, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·V López-LópezP A Cascales-Campos
Jul 25, 2021·Cancers·Roxan F C P A HeldermanJohannes Crezee

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