The effects of aerobic and anaerobic exercises on circulating soluble-Klotho and IGF-I in young and elderly adults and in CAD patients

Journal of Circulating Biomarkers
Moran S SaghivM Sagiv

Abstract

Different studies support the notion that chronic aerobic exercises training can influence the circulating levels of soluble-Klotho (s-Klotho) and insulin-like growth factor 1 (IGF-I). The effects of s-Klotho include improving the quality of life, alleviating the negative impact of age on the body's work capacity, and possibly increasing longevity. This review provides an overview of the latest findings in this field of research in humans. The different modes of dynamic exercise and their impact on circulating levels of s-Klotho and IGF-I in young adult athletes, untrained young adults, trained healthy older adults, untrained healthy older adults, and coronary artery disease (CAD) patients are reviewed and discussed. Together these findings suggest that long-lasting (chronic) aerobic exercise training is probably one of the antiaging factors that counteract the aging and CAD process by increasing the circulating s-Klotho and lowering the IGF-I levels. However, following anaerobic exercise training the opposite occurs. The exact metabolic and physiological pathways involved in the activity of these well-trained young and master sportsmen should be further studied and elucidated. The purpose of this review was to provide a clarif...Continue Reading

References

Jan 1, 1983·Medicine and Science in Sports and Exercise·D L CostillA Katz
Jun 23, 1994·The New England Journal of Medicine·M A FiataroneW J Evans
Jul 5, 1996·Science·S M Jazwinski
Jul 18, 1996·Nature·R S AhimaJ S Flier
Jul 1, 1997·International Journal of Sports Medicine·R S PaffenbargerI M Lee
Feb 10, 2000·Circulation Research·A Bayes-GenisR S Schwartz
Feb 17, 2000·The New England Journal of Medicine·R HambrechtG Schuler
Jan 25, 2002·Exercise and Sport Sciences Reviews·Mahjabeen HameedGeoffrey Goldspink
Dec 11, 2002·Journal of the American Geriatrics Society·Ellen F BinderJohn O Holloszy
May 17, 2003·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·L ThomasD L Ross
May 28, 2003·Cancer Letters·Derek LeRoith, Charles T Roberts
Mar 27, 2004·Experimental Biology and Medicine·Pu ZongH Fred Downey
Aug 27, 2005·Science·Hiroshi KurosuMakoto Kuro-o
Sep 28, 2005·The Journal of Biological Chemistry·Masaya YamamotoMakoto Kuro-o
Feb 7, 2006·Trends in Endocrinology and Metabolism : TEM·Andrzej Bartke
Apr 20, 2006·Cytokine & Growth Factor Reviews·Ron Kooijman
Mar 10, 2007·Current Pharmaceutical Design·Luigi LaviolaFrancesco Giorgino
Jan 8, 2008·Biological Chemistry·Makoto Kuro-o
Aug 6, 2008·The Journal of Cell Biology·Damian MediciBeate Lanske
Aug 20, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Darlene E BerrymanJohn J Kopchick
Nov 22, 2008·Ageing Research Reviews·Yuhong Wang, Zhongjie Sun
Jan 10, 2009·Archives of Gerontology and Geriatrics·Rodrigo Gomes de Souza ValeArmèle de Fátima Dornelas de Andrade
Feb 24, 2009·Biochimica Et Biophysica Acta·Makoto Kuro-o
May 26, 2009·The American Journal of Cardiology·Jonathan AfilaloHoward Bergman
Jun 3, 2009·Archives of Physiology and Biochemistry·Haim Werner, Ilan Bruchim
Jun 12, 2009·Medicine and Science in Sports and Exercise·Wojtek J Chodzko-ZajkoJames S Skinner
Jul 4, 2009·Journal of Science and Medicine in Sport·Masaru Teramoto, Timothy J Bungum
Jan 12, 2010·Orvosi hetilap·Péter Apor, Attila Rádi
Mar 26, 2010·Exercise and Sport Sciences Reviews·Kenneth M Baldwin, Fadia Haddad
Apr 9, 2010·Kidney International·Chou-Long Huang
Apr 9, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Richard D SembaLuigi Ferrucci
May 31, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Lisa A LesniewskiDouglas R Seals
Jul 20, 2011·European Journal of Applied Physiology·Richard D SembaLuigi Ferrucci
Sep 3, 2011·Journal of the American Geriatrics Society·Richard D SembaLuigi Ferrucci
Apr 12, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yusuke HigashiPatrice Delafontaine
Apr 24, 2012·American Heart Journal·Walter SwardfagerKrista L Lanctôt
Jun 1, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elisabeth R BartonYair Argon

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Citations

May 18, 2019·International Journal of Environmental Research and Public Health·Maha SellamiBenoit Dugué
Sep 29, 2020·Frontiers in Endocrinology·Sarah BuchananPaul G Shiels
Aug 28, 2018·Journal of Circulating Biomarkers·Sven-Jean TanStephen G Holt

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

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