The Effects of Aerobic Exercise on Cognitive and Neural Decline in Aging and Cardiovascular Disease

Current Geriatrics Reports
Scott M HayesDaniel E Forman

Abstract

Aging is characterized by a decline in cognitive functions, particularly in the domains of executive function, processing speed and episodic memory. These age-related declines are exacerbated by cardiovascular disease (CVD) and cardiovascular risk factors (hypertension, diabetes, obesity, elevated total cholesterol). Structural and functional alterations in brain regions, including the fronto-parietal and medial temporal lobes, have been linked to age- and CVD-related cognitive decline. Multiple recent studies indicate that aerobic exercise programs may slow the progression of age-related neural changes and reduce the risk for mild cognitive impairment as well as dementia. We review age- and CVD-related decline in cognition and the underlying changes in brain morphology and function, and then clarify the impact of aerobic exercise on moderating these patterns.

References

Jul 1, 1996·Psychological Review·T A Salthouse
Nov 3, 2001·Stroke; a Journal of Cerebral Circulation·N GruhnJ Aldershvile
Mar 29, 2003·Psychological Science·Stanley Colcombe, Arthur F Kramer
Jul 10, 2003·Lancet Neurology·John T O'BrienSteven T DeKosky
Jan 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karen M Rodrigue, Naftali Raz
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stanley J ColcombeSteriani Elavsky
Jun 3, 2005·Journal of Cardiopulmonary Rehabilitation·John GunstadRonald A Cohen
Aug 6, 2005·International Journal of Cardiology·David TanneYehuda Adler
Aug 12, 2005·The Journal of Urology·R Houston ThompsonMichael L Blute
Feb 24, 2006·Brain Research Reviews·Jennifer L EtnierBenjamin A Sibley
May 10, 2006·Archives of Internal Medicine·Chengxuan QiuLaura Fratiglioni
Dec 15, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stanley J ColcombeArthur F Kramer
Mar 10, 2007·European Journal of Heart Failure·Christophe Van LaethemJohan De Sutter
Mar 22, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ana C PereiraScott A Small
Sep 4, 2007·Trends in Neurosciences·Carl W CotmanLori-Ann Christie
Oct 17, 2007·Dementia and Geriatric Cognitive Disorders·Raymond L C VogelsHenry C Weinstein
Feb 29, 2008·Journal of Cognitive Neuroscience·Nancy A DennisRoberto Cabeza
Jul 9, 2008·Journal of Clinical and Experimental Neuropsychology·Ronald A CohenMarie Gerhard-Herman
Sep 2, 2008·Stroke; a Journal of Cerebral Circulation·Andreas R LuftDaniel F Hanley
Oct 3, 2008·Neurobiology of Aging·Meredith N BraskieSusan Y Bookheimer
Nov 22, 2008·Neurobiology of Disease·Rajesh KumarRonald M Harper
Mar 31, 2009·Journal of Cardiac Failure·Mary A WooRonald M Harper
Apr 8, 2009·Trends in Neurosciences·Henriette van Praag
Jul 3, 2009·Neurobiology of Aging·Kristine B WalhovdAnders M Fjell
Sep 1, 2009·Neurobiology of Aging·R RuscheweyhA Flöel
Dec 1, 2009·Clinics in Geriatric Medicine·Jacob R SattelmairDaniel E Forman
Mar 11, 2010·Nursing Research·Susan J PresslerRose Mary Shaw
Jul 22, 2010·Journal of the American Geriatrics Society·Walter SwardfagerKrista L Lanctôt
Aug 10, 2010·Cerebrovascular Diseases·Ozioma C OkonkwoAthena Poppas
Sep 9, 2010·Psychology and Aging·Andrew R BenderNaftali Raz
Sep 28, 2010·Neuropsychologia·Maureen RitcheyRoberto Cabeza
Oct 5, 2010·Frontiers in Aging Neuroscience·Michelle W VossArthur F Kramer
Nov 11, 2010·The International Journal of Neuroscience·Kelly M StanekJames Rosneck
Dec 25, 2010·AJNR. American Journal of Neuroradiology·K F HothA P Haley
Jan 26, 2011·Circulation·Paul A HeidenreichUNKNOWN Council on Cardiovascular Surgery and Anesthesia, and Interdisciplinary Council on Quality of Care and Outcomes Research
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kirk I EricksonArthur F Kramer
Mar 29, 2011·Frontiers in Human Neuroscience·Claudia Voelcker-RehageUrsula M Staudinger

❮ Previous
Next ❯

Citations

Jan 19, 2016·Frontiers in Aging Neuroscience·Udunna C AnazodoKeith S St Lawrence
Nov 20, 2015·Journal of the International Neuropsychological Society : JINS·Sara Llamas-VelascoFélix Bermejo-Pareja
Oct 6, 2015·The Journal of Physiology·Mariam El AssarLeocadio Rodríguez-Mañas
Sep 15, 2015·The Clinical Neuropsychologist·David P SheppardUNKNOWN HIV Neurobehavioral Research Program (HNRP) Group
Jul 1, 2015·Annals of Clinical and Translational Neurology·Scott M HayesMieke Verfaellie
Sep 9, 2015·Frontiers in Aging Neuroscience·Chun Liang HsuTeresa Liu-Ambrose
Apr 23, 2016·NeuroImage·Christopher R Madan, Elizabeth A Kensinger
May 21, 2016·Cancer Epidemiology·Natalie R SmithJennifer L Baker
Jun 18, 2016·Cardiovascular Psychiatry and Neurology·Vasavi R GorantlaRichard M Millis
Jun 3, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Zhezhou HuangAlicia Beeghly-Fadiel
Jun 12, 2016·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Jarosław M MichałowskiKenneth M Heilman
Sep 30, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Adrienne DorrBojana Stefanovic
Jan 21, 2017·European Journal of Heart Failure·Gilles W De KeulenaerDirk L Brutsaert
Jun 20, 2017·Journal of Neurologic Physical Therapy : JNPT·Teresa Jacobson KimberleyDeborah Larsen
Jun 28, 2017·Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association·Teresa Jacobson KimberleyDeborah Larsen
Jul 1, 2017·Nature Reviews. Cardiology·Robert H Henning, Bianca J J M Brundel
Jun 15, 2016·American Journal of Alzheimer's Disease and Other Dementias·Delaram Safarpour, Allison W Willis
Jun 13, 2018·Psychological Reports·David Green, Paul D Loprinzi
Aug 30, 2018·International Journal of Geriatric Psychiatry·Nicola VeronesePinar Soysal
May 5, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Bradley J Baranowski, Rebecca E K MacPherson
Oct 12, 2018·PloS One·Vincent KoppelmansRachael D Seidler
Jul 7, 2017·Journal of Physical Activity & Health·Carlos AyánJosé María Cancela
Jan 24, 2018·The European Journal of Neuroscience·Christopher R Madan, Elizabeth A Kensinger
Jul 21, 2017·Journal of Cardiopulmonary Rehabilitation and Prevention·Peter L PriorNeville Suskin
Sep 10, 2016·Frontiers in Aging Neuroscience·Sarah M SzymkowiczNatalie C Ebner
Mar 30, 2017·Molecular Psychiatry·N OpelU Dannlowski
Mar 28, 2017·Brain Plasticity·Davide GuerrieriHenriette van Praag
Aug 10, 2020·Scientific Reports·Mohammad MoeiniFrédéric Lesage
Aug 18, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rebecca E K MacPherson
Sep 5, 2019·Journal of Epilepsy Research·Vasavi R GorantlaRichard M Millis
Apr 25, 2020·Aging Clinical and Experimental Research·Mingzhu YeGuohua Zheng
Sep 22, 2021·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Jarosław M MichałowskiMichał Harciarek

❮ Previous
Next ❯

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