The effects of aerobic interval training on the left ventricular morphology and function of VLCAD-deficient mice.

European Journal of Applied Physiology
Charles E RiggsNancy J Smith-Blair

Abstract

This study examined the effect of aerobic interval training on cardiac adaptations in VLCAD-deficient mice and determined the effects of the deficiency on the morphology and function of the left ventricle among 53 knockout homozygous VLCAD-/-, 28 heterozygous VLCAD±, and 39 controls VLCAD+/+ male mice (129 SvJ/C57BL6). Echocardiographic images were used to determine the left ventricular (LV) wall thicknesses, during systole and diastole, acquired at a depth setting of 20 mm. Cardiac hypertrophy (as evidenced by increased wall thickness, and decreased left ventricular dimension in diastole and systole) appeared to be a major finding in the VLCAD-/- mouse with, however, normal %FS. The trained mice from all three genotypes exhibited lower body weight compared with their controls. The echocardiographic data of this study demonstrated structural but not functional differences among the three genotypes. This study demonstrated that VLCAD± deficient mice handled interval training similarly to the non-deficient mice. Four VLCAD-/- deficient mice died unexpectedly on the treadmill during the early stages of training. The VLCAD-/- deficient mice that survived adapted to the aerobic interval training similarly to the non-deficient mice. ...Continue Reading

References

Dec 1, 1982·The American Journal of Physiology·P AnversaY Kikkawa
Jan 1, 1983·Circulation Research·P AnversaY Kikkawa
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·A W StraussH F Sims
Sep 1, 1994·The American Journal of Physiology·M L KaplanP M Buttrick
Dec 26, 1995·Biochemical and Biophysical Research Communications·K O OriiT Hashimoto
Mar 14, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·C Vianey-SabanC Roe
May 20, 1998·Ryōikibetsu shōkōgun shirīzu·S Yamaguchi
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·D M KurtzP A Wood
Nov 24, 1999·The American Journal of Physiology·X P YangO A Carretero
Jun 16, 2001·Journal of Applied Physiology·G M DiffeeM M Titus
Sep 18, 2002·Journal of Applied Physiology·Ole Johan KemiØyvind Ellingsen
Aug 2, 2003·Circulation Research·Vernat J ExilArnold W Strauss
Oct 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·John F ElliottKatherine M Kavanagh
Nov 11, 2003·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Jeffrey N RottmanErnest C Madu
Aug 5, 2004·Annals of Neurology·Mette C ØRngreenJohn Vissing
Sep 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Young LeeRoger H Unger
Jan 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Andreas A WerdichVernat J Exil
Apr 26, 2007·Journal of Inherited Metabolic Disease·U Spiekerkoetter
Apr 9, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Ole Johan KemiUlrik Wisloff
Apr 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·L LeatherburyC W Lo
Feb 10, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Jian-Bing ShenBruce T Liang
Sep 9, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Keith B CoxPhilip A Wood

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Related Papers

Laboratory Investigation; a Journal of Technical Methods and Pathology
Keith B CoxPhilip A Wood
Journal of Physical Therapy Science
Gun-Soo Han, Seon-Rye Kim
American Journal of Physiology. Heart and Circulatory Physiology
Dingding XiongZaza Khuchua
© 2021 Meta ULC. All rights reserved