PMID: 7547091Jan 1, 1995Paper

The effects of age and gender on the pharmacokinetics of tenidap sodium in patients with rheumatoid arthritis and osteoarthritis

British Journal of Clinical Pharmacology
J R CaldwellR A Hansen

Abstract

1. This open-label study was conducted to evaluate the effects of age and gender on the pharmacokinetics of tenidap sodium in patients with either rheumatoid arthritis (RA) or osteoarthritis (OA). 2. A total of 145 male and female patients, 80 with RA (aged 22-91 years) and 65 with OA (aged 45-83 years) each received a single dose of 120 mg tenidap sodium. Pharmacokinetic parameters were estimated from individual tenidap plasma concentration-time curves determined up to 120 h post-dose. Tenidap plasma protein binding was determined in the youngest and oldest age groups for both RA and OA patients. 3. In RA patients, age and gender did not significantly affect the disposition of tenidap or the percentage of unbound tenidap in plasma. Only for tmax were statistically significant effects in the analysis of covariance observed and these were attributed to very high tmax values in two female patients. Likewise, in patients with OA, age and gender did not significantly affect the pharmacokinetics of tenidap, although patients with larger body weights had lower Cmax values. 4. Pharmacokinetic parameters were not significantly different between RA and OA patients, except for t1/2, where two outlier RA patients had low values that cause...Continue Reading

References

Feb 1, 1990·The Biochemical Journal·P C HeinrichT Andus
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M HattoriG H Fey
Jan 1, 1989·Scandinavian Journal of Rheumatology. Supplement·M Schmitt, T W Guentert
Jan 1, 1984·Scandinavian Journal of Rheumatology·J S DixonV Wright
Aug 1, 1984·British Journal of Clinical Pharmacology·R A UptonR M Jones
Jan 1, 1983·European Journal of Clinical Pharmacology·Z Trnavská, K Trnavský
Jul 1, 1983·British Journal of Clinical Pharmacology·C AdvenierB Flouvat
Jan 1, 1995·British Journal of Clinical Pharmacology·K D Wilner, M J Gardner

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