The effects of age on exhaled breath nitric oxide levels.

Lung
Robert R HaightStuart M Brooks

Abstract

A variety of factors influence exhaled breath nitric oxide (ENO) but few studies have examined ENO at the extremes of adult age. This investigation explores whether there is a difference in ENO between groups of older and younger individuals. A total of 48 normal subjects consisting of 23 younger (median age - 24 years) and 25 older (median age - 72 years) participants were studied. Carefully defined clinical and spirometric parameters, smoking history, and drug/medication documentation were determined to insure normalcy. Measurements of ENO were made using ATS/ERS recommended methodologies. The older group consistently showed higher ENO concentrations than-the younger subjects; median ENO values were 36.9 and 18.7 ppb, respectively (p < 0.001). The statistical significance held true when adjusting for multiple testing with the Holm method and accounting for outliers and medication usage. ENO levels are significantly higher in a normal older population. Comparing ENO between individuals at the extremes of age may depict differences more decidedly. Whether elevated ENO reflects underlying airway inflammation in older persons remains unanswered. It is possible that the difference in NO concentrations between older and younger gro...Continue Reading

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Citations

Jun 7, 2013·Aging Clinical and Experimental Research·Giovanna Elisiana CarpagnanoMaria Pia Foschino Barbaro
Feb 6, 2010·The Journal of Allergy and Clinical Immunology·Sylvia VerbanckWalter Vincken
Jul 24, 2007·Respiration; International Review of Thoracic Diseases·Jia LiuPaul S Thomas
May 21, 2015·Journal of Breath Research·Tiago JacintoKjell Alving
May 12, 2015·Expert Review of Molecular Diagnostics·Simone ScarlataRaffaele Antonelli Incalzi
Feb 20, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Hasib AhmadzaiQi Zhang
Jun 12, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Sang-Heon KimSung Soo Park
Sep 22, 2017·Scientific Reports·Simone ScarlataRaffaele Antonelli Incalzi

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