The effects of ageing on dental pulp stem cells, the tooth longevity elixir

European Cells & Materials
I IezziT A Mitsiadis

Abstract

Stem cells are essential for tissue homeostasis and regeneration throughout the lifespan of multicellular organisms. The decline in stem cell function during advanced age is associated with a reduced regenerative potential of tissues that leads to an increased frequency of diseases. Age-related changes also occur in the dental pulp that represents a reliable model tissue, with high regenerative capability, for studying senescence mechanisms. However, little information is available concerning the effects of ageing on dental stem-cell function. In this mini-review, recent data on how the molecular and functional alterations that accumulate in stem cell populations during ageing result in modifications of dental pulp physiology are discussed. Changes that accumulate during ageing such as how reduction of pulp chamber volume, decreased vascular supply and modifications to the stem cell niches affect stem cell functions and, therefore, dental pulp regenerative potential in response to various stressful agents. Dental pulp cells from aged individuals are still metabolically active and secrete pro-inflammatory and matrix-degrading molecules. Furthermore, miRNAs and exosomes derived from dental pulp stem cells constitute an attractiv...Continue Reading

Citations

Sep 25, 2020·International Journal of Molecular Sciences·Mohammed Zayed, Koichiro Iohara
Sep 21, 2020·Journal of Endodontics·Gottfried SchmalzKerstin M Galler
Dec 10, 2020·The Journal of the American Dental Association·Pi-En ChangYoon Jeong Choi
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Hidefumi Maeda
Feb 16, 2021·Frontiers in Bioengineering and Biotechnology·Begoña M BoschRoman A Perez

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