PMID: 22563664May 9, 2012Paper

The effects of ageing on proliferation potential, differentiation potential and cell surface characterisation of human mesenchymal stem cells

Current Stem Cell Research & Therapy
Emma FossettAdetola B Adesida

Abstract

Mesenchymal stem cells (MSCs) have a great capacity for use in regenerative medicine and other clinical applications. However, one question creating curiosity of their use, is how they are affected by ageing. As we now live within an ageing population, the prevalence of age related disorders is increasing, so it is important to investigate how effectively MSCs from older patients can be expanded and differentiated in vitro before their use in autologous cell transplantation. This paper will look at how ageing effects proliferation potential, differentiation potential and cell surface characterisation of human mesenchymal stem cells.

Citations

Oct 3, 2012·PloS One·Maria BrohlinMikael Wiberg
Mar 13, 2013·Regenerative Medicine·Ursula StochajInés Colmegna
Dec 10, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Benjamin M DaviesAndrew J Price
Apr 4, 2017·Journal of Cellular Physiology·Eiman Abdel MeguidAhmed H K El-Hashash
Aug 25, 2017·Stem Cells International·Katsunori ShiraishiMitsuo Ochi

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