The effects of aging and disease duration on cognition in multiple sclerosis.

Brain and Cognition
Alexandra TremblayIsabelle Rouleau

Abstract

Multiple sclerosis (MS) is a disease of the central nervous system that can interfere with cognitive functions. The purpose of this study is to document the impact of MS, aging and disease duration on cognitive functioning as both life expectancy and incidence of the disease among persons with MS (PwMS) aged 50 years and over (late-onset MS) are increasing in the last two decades. Exhaustive neuropsychological evaluation was performed in 84 PwMS (30 young, 30 elderly adult-onset, 25 elderly late-onset) and 50 control participants (25 young, 24 elderly). ANCOVAs and hierarchical linear regressions were used to meet the objectives. Interaction effects were found between age and presence of MS on higher executive function and information processing speed/working memory. After controlling for confounding variables (fatigue, quality of life, depression, MS course, comorbidity), results demonstrated an important role of age on all cognitive functions but only a trend of disease duration on information processing speed/working memory. Decline in higher executive functions and information processing speed/working memory in aging is accentuated by the presence of MS, but the impact of age and MS on memory are independent. Age appears to...Continue Reading

References

Jan 1, 1990·Gerontology·A D WhiteD A Compston
Feb 24, 2001·Journal of the American Geriatrics Society·M L PolliackA Achiron
Apr 20, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·D M WingerchukJ H Noseworthy
Jun 1, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·R ZivadinovM Zorzon
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Feb 25, 2005·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·V MartinelliG Comi
Nov 12, 2005·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Apr 29, 2006·Journal of the Neurological Sciences·Maria Pia AmatoEmilio Portaccio
Sep 20, 2006·Journal of the International Neuropsychological Society : JINS·Ralph H B BenedictBianca Weinstock-Guttman
Sep 27, 2006·Neurology·Helen Tremlett, Virginia Devonshire
Sep 22, 2007·Lancet Neurology·David H Miller, Siobhan M Leary
Nov 15, 2008·Lancet Neurology·Nancy D Chiaravalloti, John DeLuca
May 27, 2009·Neuropsychologia·Yaakov Stern
Oct 13, 2009·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Angela M BodlingSharon G Lynch
Feb 23, 2010·La Presse médicale·David Brassat
Apr 3, 2010·Drugs & Aging·Amer Awad, Olaf Stüve
May 25, 2010·Physical Medicine and Rehabilitation Clinics of North America·Michelle SternKevin Sperber
Jul 9, 2010·Journal of the International Neuropsychological Society : JINS·Ralph H B BenedictDavid J Schretlen
Jul 14, 2010·Nature Reviews. Neurology·Massimiliano CalabresePaolo Gallo
Dec 2, 2010·Women's Health·Céline JobinPierre Duquette
Mar 29, 2011·Neurologic Clinics·Laura J Julian
Oct 11, 2011·Biochimica Et Biophysica Acta·Jason Steffener, Yaakov Stern
Apr 30, 2013·La Revue de médecine interne·M SalouD-A Laplaud
Jan 15, 2015·Multiple Sclerosis : Clinical and Laboratory Research·C SolaroM A Battaglia
Aug 8, 2015·Nature Reviews. Immunology·Calliope A DendrouManuel A Friese
Nov 4, 2015·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Marijean Buhse
Feb 21, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Shaik Ahmed SanaiBianca Weinstock-Guttman
May 22, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Silvana L CostaNancy D Chiaravalloti
Jun 24, 2016·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Nikolaos Korakas, Magda Tsolaki
Nov 26, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Shumita RoyRalph Hb Benedict
Feb 1, 2019·Neuropsychology·Gabriella SantangeloLuigi Trojano
Apr 20, 2019·Nature Reviews. Neurology·Caila B VaughnBianca Weinstock-Guttman
May 28, 2019·Frontiers in Aging Neuroscience·Dejan JakimovskiRalph H B Benedict

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Akitoshi Takeda
Gériatrie et psychologie neuropsychiatrie du vieillissement
Céline LouapreElisabeth Maillart
The Journal of Neuropsychiatry and Clinical Neurosciences
Sarah A MorrowKoula Pantazopoulos
CNS & Neurological Disorders Drug Targets
T F RuniaR Q Hintzen
© 2021 Meta ULC. All rights reserved