The effects of aging on hypoglossal motoneurons in rats.

Dysphagia
Emilie C SchwarzM Behan

Abstract

Aging can result in a loss of neuronal cell bodies and a decrease in neuronal size in some regions of the brain and spinal cord. Motoneuron loss in the spinal cord is thought to contribute to the progressive decline in muscle mass and strength that occurs with age (sarcopenia). Swallowing disorders represent a large clinical problem in elderly persons; however, age-related alterations in cranial motoneurons that innervate muscles involved in swallowing have been understudied. We aimed to determine if age-related alterations occurred in the hypoglossal nucleus in the brainstem. If present, these changes might help explain alterations at the neuromuscular junction and changes in the contractile properties of tongue muscle that have been reported in older rats. We hypothesized that with increasing age there would be a loss of motoneurons and a reduction in neuronal size and the number of primary dendrites associated with each hypoglossal motoneuron. Neurons in the hypoglossal nucleus were visualized with the neuronal marker NeuN in young (9-10 months), middle-aged (24-25 months), and old (32-33 months) male F344/BN rats. Hypoglossal motoneurons were retrograde-labeled with injections of Cholera Toxin beta into the genioglossus mus...Continue Reading

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Citations

May 9, 2012·Experimental Brain Research·Jaime N BaskenMichelle R Ciucci
Apr 28, 2012·Dysphagia·Fumiyo TamuraKen Yaegaki
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Feb 8, 2018·Journal of Neurophysiology·Matthew J FogartyGary C Sieck
Jul 30, 2021·Journal of Applied Physiology·Matthew J Fogarty, Gary C Sieck

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