The Effects of Aging on the Multifocal Electroretinogram

Japanese Journal of Ophthalmology
T Nabeshima

Abstract

Purpose: In order to use multifocal electroretinogram (m-ERG) for clinical assessment, we investigated the effects of aging on waves of the first and second order kernels of the m-ERG.Subjects and Methods: m-ERGs were recorded from 93 eyes (refractive error 0 to -3. 0 D) of 56 normal subjects (range, 12-79, mean, 44.2 +/- 20. 7 years of age) using the Visual Evoked Response Imaging System (VERIS Science((R)), version 3.0.1). We analyzed effects of aging on the response densities and the peak latencies of the first positive wave (P 1) of the first order kernel and the second and third positive waves (P 2 and P 3) of the second order kernel.Results: The response densities of the P 1 and P 2 waves significantly decreased, and the peak latencies of the P 1, P 2 and P 3 were significantly prolonged (P < 0.05) in the subjects above 50 years old.Conclusion: The results suggested that the aging effect on the m-ERG should be considered when evaluating retinal function using m-ERGs in basic and clinical studies.

Citations

Jan 10, 2002·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Gregory R JacksonCynthia Owsley
Dec 25, 2004·Eye·W-K TamM Yap
Oct 1, 2018·The British Journal of Ophthalmology·Ruofan Connie HanJasleen Kaur Jolly
Jan 11, 2007·Survey of Ophthalmology·Timothy Y Y LaiDennis S C Lam

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.