The effects of alcohol-containing e-cigarettes on young adult smokers

Drug and Alcohol Dependence
Gerald W ValentineMehmet Sofuoglu

Abstract

The liquids (e-liquids) used in an electronic cigarette (e-cigarette) contain myriad chemicals without adequate human inhalation safety data. Furthermore, the absence of e-liquid labeling requirements poses a formidable challenge to understanding how e-liquid constituents may promote nicotine addiction and/or have independent or synergistic biological effects when combined with nicotine. Ethyl alcohol is such a constituent, but has received little scientific interest in this context. Using a randomized, double blind, crossover design, acute changes in subjective drug effects, motor performance and biochemical measures of alcohol and nicotine intake were evaluated after directed and ad lib puffing from two commercially available e-liquids containing nicotine (8 mg/ml), vanilla flavor and either 23.5% (high) or 0.4% (trace) alcohol. While no differences in subjective drug effects were observed between alcohol conditions, performance on the Purdue Pegboard Dexterity Test (PPDT) improved under the trace, but not under the 23.5% alcohol condition. Although plasma alcohol levels remained undetectable during testing, urine ethyl glucuronide (EtG), an alcohol metabolite, became measurable in three participants after puffing from the 23...Continue Reading

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Citations

Jan 6, 2017·Alcoholism, Clinical and Experimental Research·Robert Ross MacLeanMehmet Sofuoglu
Apr 18, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Elise E DeVitoMehmet Sofuoglu
Jul 6, 2018·Analytical and Bioanalytical Chemistry·Ryan F LeBoufAleksandr B Stefaniak
Apr 18, 2020·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Dazhe James CaoSing-Yi Feng
Sep 27, 2019·Current Addiction Reports·Krysten W Bold, Suchitra Krishnan-Sarin
Nov 24, 2020·Frontiers in Physiology·Tanner J Wetzel, Todd A Wyatt
Apr 30, 2021·The Cochrane Database of Systematic Reviews·Jamie Hartmann-BoycePeter Hajek
Oct 15, 2020·The Cochrane Database of Systematic Reviews·Jamie Hartmann-BoycePeter Hajek
May 22, 2021·Environmental Science & Technology·Ruwini D RajapakshaCharles C Harb
Sep 15, 2021·The Cochrane Database of Systematic Reviews·Jamie Hartmann-BoycePeter Hajek
Nov 16, 2021·Frontiers in Chemistry·Alaina K HoltMichelle R Peace

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