PMID: 9179508Apr 14, 1997Paper

The effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers

Drug and Alcohol Dependence
A M ChoJ P Zacny

Abstract

The purpose of this study was to characterize the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers with different alcohol histories. Subjects were divided into two groups: light drinkers (n = 9) and moderate drinkers (n = 10). A choice procedure was used in which subjects first sampled placebo and a given concentration of nitrous oxide, and then chose between the two. Nitrous oxide concentration varied across the four-session experiment from 10-40%. Besides choice, subjective and psychomotor effects served as dependent measures. The majority of subjective effects of nitrous oxide, and its psychomotor-impairing effects, did not vary as a function of drinking group. However, a Wilcoxon rank sum test showed that the median number of times moderate drinkers chose nitrous oxide (three) was significantly higher than the median number of times light drinkers chose nitrous oxide (one). This study provides suggestive evidence that the reinforcing effects of nitrous oxide are modulated by alcohol history.

References

Jan 1, 1977·Acta Anaesthesiologica Scandinavica·T Tammisto, I Tigerstedt
Mar 1, 1978·Behavior Genetics·G Whitney, G P Horowitz
Aug 1, 1992·Pharmacology, Biochemistry, and Behavior·T SuzukiR A Meisch
Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·F R GeorgeS R Goldberg
May 1, 1991·Pharmacology & Toxicology·E J Nuotto, K T Korttila
May 1, 1989·Pharmacology, Biochemistry, and Behavior·H deWitC E Johanson
Jun 1, 1989·Pharmacology, Biochemistry, and Behavior·J L Falk, M Tang
Jan 1, 1985·Psychopharmacology·J Bergman, C E Johanson
Jan 1, 1973·Acta Anaesthesiologica Scandinavica. Supplementum·T Tammisto, S Takki
Jul 1, 1969·Anesthesia and Analgesia·S R Keilty
Dec 1, 1983·Pharmacology, Biochemistry, and Behavior·I GellerE M Gause
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·C R Schuster, C E Johanson
Jan 1, 1981·British Journal of Anaesthesia·D D Koblin, J E Deady
Apr 1, 1995·Pharmacology, Biochemistry, and Behavior·C J MeliskaR A Jensen
Jan 1, 1993·Psychopharmacology·P Hyyatiä, J D Sinclair
Dec 1, 1993·Pharmacology, Biochemistry, and Behavior·C S DohrnJ P Zacny
Feb 1, 1993·Drug and Alcohol Dependence·C S DohrnJ P Zacny
Jan 1, 1996·Psychopharmacology·S M EvansH de Wit

❮ Previous
Next ❯

Citations

May 7, 2003·Drug and Alcohol Dependence·Allison Dorlen Pastor, Suzette M Evans
Oct 24, 2002·Behavioural Pharmacology·S M Evans, F R Levin
Jul 30, 2010·Drug and Alcohol Dependence·James P Zacny, Jenny M Jun
Jul 22, 2008·Drug and Alcohol Dependence·James P ZacnyLindsay M Derus
Dec 14, 2007·Drug and Alcohol Dependence·James P ZacnyMolly Sells
Dec 17, 2010·Alcoholism, Clinical and Experimental Research·Matthew D StanleyCraig R Rush
May 27, 2003·Alcoholism, Clinical and Experimental Research·William W StoopsCraig R Rush
Jan 29, 2002·The Journal of the American Dental Association·James P ZacnyDebra J Janiszewski
Jul 25, 2006·The International Journal of Neuroscience·Ann E K KosobudGeorge V Rebec

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.