The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizures.

Neurochemical Research
Adriana da Rocha ToméR M Freitas

Abstract

Reactive oxygen species have been implicated in seizure-induced neurodegeneration, and there is a correlation between free radical level and scavenger enzymatic activity in the epilepsy. It has been suggested that pilocarpine-induced seizures is mediated by an increase in oxidative stress. Current research has found that antioxidant may provide, in a certain degree, neuroprotection against the neurotoxicity of seizures at the cellular level. Alpha-tocopherol has numerous nonenzymatic actions and is a powerful liposoluble antioxidant. The objective of the present study was to evaluate the neuroprotective effects of alpha-tocopherol (TP) in rats, against oxidative stress caused by pilocarpine-induced seizures. 30 min prior to behavioral observation, Wistar rats were treated with, 0.9% saline (i.p., control group), TP (200 mg/kg, i.p., TP group), pilocarpine (400 mg/kg, i.p., P400 group), or the combination of TP (200 mg/kg, i.p.) and pilocarpine (400 mg/kg, i.p.). After the treatments all groups were observed for 6 h. The enzymatic activities, lipid peroxidation and nitrite concentrations were measured using speccitrophotometric methods and these data were assayed. In P400 group mice there was a significant increase in lipid pero...Continue Reading

References

Nov 1, 1991·Cancer Causes & Control : CCC·K A Steinmetz, J D Potter
Jan 1, 1990·Methods in Enzymology·H H Draper, M Hadley
Jan 1, 1984·Methods in Enzymology·L Flohé, F Otting
Apr 3, 1981·Science·L C GreenP Goldman
Jul 1, 1995·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·D M Treiman
Jun 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·J M McCord
Feb 1, 1997·The American Journal of Physiology·H M SaidC K Valerio
Jun 5, 1999·The American Journal of Clinical Nutrition·A C Carr, B Frei
Apr 13, 2000·The European Journal of Neuroscience·M V FrantsevaP L Carlen
May 8, 2000·Alcoholism, Clinical and Experimental Research·M B HeatonM Paiva
Feb 13, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·K SudhaA Rao
Jul 11, 2001·Journal of the American College of Nutrition·J A SimonJ A Tice
May 12, 2004·Current Pharmaceutical Design·Carlo M BergaminiCarlo Cervellati
Dec 14, 2004·Neuroscience and Behavioral Physiology·L S GodlevskiiL M Bobkova
Jan 18, 2005·Alcoholism, Clinical and Experimental Research·Tuan D TranCharles R Goodlett
Mar 9, 2005·The FEBS Journal·Rivelilson M FreitasMarta M F Fonteles
Apr 29, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richard KovácsOliver Kann
May 17, 2005·Pharmacology, Biochemistry, and Behavior·Janusz SzyndlerAdam Płaźnik
Aug 6, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J M Tucker, D M Townsend
Sep 16, 2005·Epilepsy Research·Marinei Cristina Pereira RibeiroCarlos Fernando Mello
Dec 27, 2005·Brain Research Bulletin·Mustafa AyyildizA Kasim Baltaci
May 2, 2006·Brain Research Bulletin·S TejadaS Esteban
Jun 30, 2006·Neurobiology of Disease·Miroslav GottliebCarlos Matute
Jul 29, 2008·Advanced Drug Delivery Reviews·Annette MaczurekGerald Münch

❮ Previous
Next ❯

Citations

Mar 1, 2012·Cellular and Molecular Neurobiology·Dayane Alves CostaRivelilson Mendes de Freitas
Feb 14, 2012·The Journal of Pain : Official Journal of the American Pain Society·Lorenzo Di Cesare MannelliCarla Ghelardini
Nov 22, 2014·Neurological Research·Saeed MehrzadiHabib Ghaznavi
Dec 2, 2011·Pharmaceutical Biology·Joaquim S da Costa JúniorRivelilson Mendes de Freitas
Jun 16, 2011·Neurochemistry International·Eun-Joo ShinHyoung-Chun Kim
Sep 11, 2012·Pharmacology, Biochemistry, and Behavior·Saulo Fábio RamosVanessa Moraes de Andrade
Jul 13, 2011·European Journal of Pharmacology·Pauline Sousa dos SantosRivelilson Mendes de Freitas
Nov 28, 2015·BioMed Research International·Giorgio La FataM Hasan Mohajeri
Sep 13, 2016·Nutritional Neuroscience·Youssef BahbitiAbdelhalem Mesfioui
Sep 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rita CitraroGiovambattista De Sarro
Dec 17, 2016·International Journal of Molecular Sciences·Patrizia AmbroginiAndrea Minelli
Jun 13, 2019·Nutrients·Ji-Eun Kim, Kyung-Ok Cho
Oct 29, 2019·Behavioural Pharmacology·Amal Mohamed Mahfoz, Naiyer Shahzad
Aug 4, 2020·Journal of Alzheimer's Disease : JAD·Francisca A de LeeuwMartha Clare Morris
May 20, 2014·ACS Chemical Neuroscience·Guanqun ZhengMark J Olsen
Sep 21, 2018·Brain Research Bulletin·Rosângela Figueiredo Mendes-da-SilvaRubem Carlos Araújo Guedes
Feb 14, 2012·Journal of Agricultural and Food Chemistry·Hsiao-Ling HuangChien-Wei Hou
Sep 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Aman B UpaganlawarTapan Behl
Jul 4, 2012·Neuroscience Letters·J P CostaR M Freitas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.