PMID: 4288206Aug 1, 1966Paper

The effects of alteration of blood-volume on the concentration of circulating angiotensin in anaesthetized dogs

The Journal of Physiology
R L HodgeJ R Vane

Abstract

1. The blood-bathed organ technique was used to assay the concentration of angiotensin in the blood of anaesthetized dogs.2. Alterations of blood volume caused inverse changes of angiotensin concentration owing to changes in the rate of generation of angiotensin which are probably due to changes of the rate of renin secretion.3. Haemorrhage of 14-26 ml. blood/kg caused an increase of 0.25-1.5 mug/min in the rate of generation and an increase of 0.1-0.33 ng/ml. in the blood concentration of angiotensin.4. The changes of angiotensin generation rate were not due to changes of renal arterial or venous pressure. They were abolished by blocking the renal nerves with lignocaine; they showed a consistent inverse correlation with central venous pressure but not with systemic arterial pressure.5. It is concluded that changes of blood volume bring about changes of the rate of generation of angiotensin by a reflex mechanism the efferent limb of which involves the renal nerves. The afferent pathway remains to be elucidated, but the systemic baroceptors do not appear to be of primary importance.6. The renin-angiotensin system is important in the homeostatic response to changes of blood volume.

Citations

Dec 1, 1973·The Japanese Journal of Surgery·H YogoY Itasaka
Dec 1, 1973·Annals of Biomedical Engineering·D S GannJ D Schoeffler
Aug 1, 1967·British Journal of Pharmacology and Chemotherapy·J Staszewska-Barczak, J R Vane
Jan 1, 1983·World Journal of Surgery·D S Gann, M P Lilly
Jun 1, 1974·Australian and New Zealand Journal of Medicine·R Vandongen
May 1, 1971·Australian and New Zealand Journal of Medicine·J P CoghlanR D Wright
Oct 1, 1967·Acta Physiologica Scandinavica·L Bozović, J Castenfors
Jan 1, 1980·Clinical and Experimental Hypertension : CHE·R Couture, D Regoli
Jul 16, 2010·Pharmacological Reports : PR·Ryszard J Gryglewski, Zygmunt Mackiewicz
Jun 1, 1969·The American Journal of Medicine·D H StreetenT G Dalakos
Jul 1, 1974·Clinical and Experimental Pharmacology & Physiology·H TanigawaT A Assaykeen
Jul 1, 1970·British Journal of Pharmacology·R Gryglewski, J R Vane
Apr 1, 1970·British Journal of Pharmacology·N J Gilore, J R Vane
Sep 16, 1967·Nature·S H Ferreira, J R Vane
Apr 13, 1968·Nature·K K Ng, J R Vane
Dec 1, 1995·The Journal of Trauma·K A LudwigC Aprahamian
May 3, 2006·Kidney & Blood Pressure Research·Zuzana HuskováLudek Cervenka
Mar 25, 1974·Pflügers Archiv : European journal of physiology·S K James, R C Hall
Feb 22, 1978·Pflügers Archiv : European journal of physiology·B GrandjeanJ Sassard
Jan 1, 1970·Pflügers Archiv : European journal of physiology·H DahlheimK Thurau
Mar 1, 1972·Circulation Research·C M FerrarioJ W McCubbin
Aug 1, 1968·Circulation·Y KanekoH Ueda
Apr 1, 1977·Biulleten' eksperimental'noĭ biologii i meditsiny·N NachevL Iordanova
Apr 21, 1969·Annals of the New York Academy of Sciences·D S Gann
Jun 1, 1978·Archives of Disease in Childhood·M J DillonR D Milner
Nov 1, 1971·Australian and New Zealand Journal of Medicine·F A Mendelsohn, C I Johnston
Feb 1, 1973·Circulation Research·R VandongenG W Boyd
Feb 1, 1969·British Journal of Pharmacology·J R Vane
Jun 1, 1975·British Journal of Pharmacology·B N Davies, P G Withrington
Mar 1, 1970·Klinische Wochenschrift·K A MeurerW Kaufmann
Mar 9, 1972·The New England Journal of Medicine·M D ThamesH E De Wardener
Sep 15, 1971·Klinische Wochenschrift·K A Meurer
Dec 1, 1974·Scandinavian Journal of Clinical and Laboratory Investigation·I EideF Kill

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