The effects of alternating electric fields in glioblastoma: current evidence on therapeutic mechanisms and clinical outcomes

Neurosurgical Focus
Azeem A RehmanTobias A Mattei

Abstract

Glioblastoma is both the most common and most lethal primary CNS malignancy in adults, accounting for 45.6% of all malignant CNS tumors, with a 5-year survival rate of only 5.0%, despite the utilization of multimodal therapy including resection, chemotherapy, and radiation. Currently available treatment options for glioblastoma often remain limited, offering brief periods of improved survival, but with substantial side effects. As such, improvements in current treatment strategies or, more likely, the implementation of novel strategies altogether are warranted. In this topic review, the authors provide a comprehensive review on the potential of alternating electric fields (AEFs) in the treatment of glioblastoma. Alternating electric fields-also known as tumor-treating fields (TTFs)-represent an entirely original therapeutic modality with preliminary studies suggesting comparable, and at times improved, efficacy to standard chemotherapeutic agents in the treatment of recurrent glioblastoma. A recent multicenter, Phase III, randomized clinical trial comparing NovoTTF-100A monotherapy to physician's best choice chemotherapy in patients with recurrent glioblastoma revealed that AEFs have similar efficacy to standard chemotherapeuti...Continue Reading

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Citations

Feb 5, 2016·Acta neurochirurgica·Thomas Mindermann
Mar 20, 2016·Acta neurochirurgica·Thomas Mindermann, Aminadav Mendelowitsch
Jun 17, 2016·Expert Review of Neurotherapeutics·Antonin DréanAhmed Idbaih
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Sep 4, 2021·Bioelectricity·Jade A PhillipsMustafa B A Djamgoz

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Methods Mentioned

BETA
biosensors
biosensor
fluorescence microscopy
biopsies

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