The effects of amantadine, rimantadine and levodopa on the frequency of fibrillation potentials in denervated muscle

Electroencephalography and Clinical Neurophysiology
I Yaar

Abstract

Right mid-thigh sciatic denervation was performed in 59 rats. Eleven days later they were assigned into 4 groups: a control group that was injected intraperitoneally with normal saline, and 3 test groups that were injected intraperitoneally with amantadine, rimantadine or levodopa (50 mg/kg each), for 3 consecutive days. On the fourteenth day, 2 h after the third injection, electromyography of the soleus-gastrocnemius muscles was performed under pentothal anesthesia. Fibrillation potentials were counted. The statistical analysis showed significant reduction of fibrillations secondary to levodopa and to amantadine injections. Rimantadine did not change the frequency of fibrillations. A stabilizing effect of levodopa and amantadine on the denervated plasmalemma is postulated.

References

May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A T EldefrawiB Witkop
Jul 1, 1978·Clinical and Experimental Pharmacology & Physiology·W C Bowman, M W Nott
Dec 6, 1974·Brain Research·O LindvallU Stenevi
Nov 1, 1969·Toxicology and Applied Pharmacology·V G VernierD H Smith
Feb 10, 1967·Annals of the New York Academy of Sciences·W C Bowman, C Raper

Citations

Sep 1, 1967·European Journal of Pharmacology·C Raper, A Jowett

Related Concepts

Acetilcolina Cusi
Adamantane
Wiregyt
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Surface Electromyography
Levopa
Inotropism
Muscle Denervation Procedure
Cholinergic Receptors
Roflual

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